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Advanced Imaging Technology Lab
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The lab studies the pathology of organs through imaging, using tools such as high-field MRI.
AboutAbout the lab
Using advanced imaging technology to understand the pathology of organs.
The Advanced Imaging Technology Lab develops advanced diagnostic imaging technologies in radiological technology and magnetic resonance medicine, aiming to evaluate diseases of organs such as the brain, lungs, heart, and liver and to elucidate their pathology.
With access to a preclinical ultra-high-field 7T MRI, a permanent-magnet 1.5T MRI, micro-CT, and other equipment, the lab examines disease models in animals such as rats and mice through imaging.
The lab welcomes students who want to work clinically in hospitals as radiologic technologists, as well as students aiming to become researchers or university faculty.
Key terms
- 7T-MRI
- An ultra-high-field MRI scanner with a magnetic field strength of 7 tesla. The lab has a preclinical system.
- CEST
- Chemical exchange saturation transfer imaging. An MRI technique used, for example, to image creatine.
- Imaging biomarker
- An indicator for reading disease pathology or treatment effects from images
ResearchResearch themes
Using equipment such as a preclinical 7T MRI and micro-CT, the lab aims to develop advanced diagnostic imaging technologies, evaluate diseases of organs such as the brain, lungs, heart, and liver, and elucidate their pathology. It applies advanced imaging technologies to disease models of the brain, heart, liver, and other organs, seeking to capture the nature of disease in images.
*Illustrative imageBuilding a Foundation for Preclinical Imaging
The Division of Health Sciences has introduced a preclinical 1.5T MRI, a 7T MRI, and a micro-CT for small animals. The lab is also involved in managing and operating a preclinical 7T MRI at the National Cerebral and Cardiovascular Center, and develops advanced imaging technologies and technologies for diagnosing pathology using high-field MRI at these two facilities.
*Illustrative imageDiagnostic Imaging of Brain Disease Models
For brain diseases such as cerebral infarction and Parkinson's disease, the lab applies advanced diagnostic imaging technologies such as water molecule diffusion imaging and chemical exchange saturation transfer (CEST) imaging. It aims to find new imaging biomarkers that can be used to diagnose pathology and assess treatment effects.
*Illustrative imageCardiac Function Imaging of Heart Disease Models
Using a preclinical ultra-high-field 7T MRI, the lab develops cardiac function imaging that captures rodent hearts at a high resolution of under 100 μm, as well as imaging methods for myocardial tissue characterization, and applies them to heart disease models. It aims to detect heart disease early and to detect degeneration of myocardial tissue that is not accompanied by morphological changes.
*Illustrative imageImaging of Liver, Lower Limb, and Joint Disease Models
In organs and tissues such as the liver, kidneys, muscles, and joints, the lab applies contrast agents and advanced diagnostic imaging technologies to image organ function and metabolism. In joint research with the Department of Medical Biochemistry, Graduate School of Frontier Biosciences, Osaka University, it established Cr-CEST, a molecular imaging method for creatine.
MembersFaculty
- Associate ProfessorShigeyoshi Saito
VoicesStudent voices
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “MRI installation” Laboratory of Functional and Molecular Imaging, NINDS, NIH / Public domain (cropped)
- Building a Foundation for Preclinical Imaging: “Preclinical Small-Animal MRI System (NIH BioArt )” Courtesy of NIAID Malcolm Houston / Public domain (cropped)
- Diagnostic Imaging of Brain Disease Models: “DTI-sagittal-fibers” Thomas Schultz / CC BY-SA 3.0 (cropped)
- Cardiac Function Imaging of Heart Disease Models: “Cardiac mri slice bionerd” Bionerd / CC BY-SA 3.0 (cropped)
- Imaging of Liver, Lower Limb, and Joint Disease Models: “CECT Abdomen Pelvis Scan Imaging” Goleisureintl / CC BY 4.0 (cropped)
- Related lab (Acute and Palliative Care Lab): “Patient lying in hospital bed in intensive care unit in Germany in 2015” Pittigrilli / CC BY-SA 4.0 (cropped)
- Related lab (Perioperative Management Lab): “AusMAT team members performing surgery ( )” Department of Foreign Affairs and Trade / CC BY 2.0 (cropped)
- Related lab (Psychiatric and Mental Health Nursing Lab): “Nursing staff, St Mary's Hospital” Ardosion / CC BY-SA 4.0 (cropped)
- Related lab (Chronic Illness Nursing Lab): “Nurse checks blood pressure” Linda Bartlett (Photographer) / Public domain (cropped)
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