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Radiation Therapy Biology Lab
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The lab studies cancer treatment using radiation from a biological perspective.

AboutAbout the lab
Supporting radiation-based cancer treatment through biology
The Radiation Therapy Biology Lab studies cancer treatment using various types of radiation from a biological perspective.
Using X-rays, gamma rays, particle beams, neutron beams, and other types of radiation, the lab investigates topics such as combinations of radiation and immune checkpoint inhibitors.
In collaboration with the Department of Radiation Oncology in the Department of Medicine and the Medical Physics Lab in the Department of Health Sciences, the lab aims to improve treatment outcomes for cancer patients.
The lab also collaborates with institutions in Japan and abroad, including the Hyogo Ion Beam Medical Center and City of Hope in the United States.
Key terms
- Abscopal effect
- A phenomenon in which a therapeutic effect appears not only in the irradiated tumor but also in tumors that were not irradiated.
- Immune checkpoint inhibitor
- A drug that treats cancer by harnessing the immune system. This lab examines the effects of combining it with radiation.
- Cancer antigen
- Information carried by cancer cells. It is considered important for activating immunity against cancer.
NewsLab news
Project Assistant Professor Shohei Katsuki received the Outstanding Paper Award of the Division of Health Sciences
A student received the Osaka University Outstanding Research Award for Female Graduate Students
A paper with Project Assistant Professor Shohei Katsuki as first author was accepted by the Journal of Radiation Research
The Radiation Therapy Biology Lab was established
ResearchResearch themes
The Radiation Therapy Biology Lab conducts biological research toward controlling cancer treatment using various types of radiation, including X-rays, gamma rays, particle beams, and neutron beams. The lab works closely with the Department of Radiation Oncology in the Department of Medicine and carries out joint research activities.
*Illustrative imageInvestigating the abscopal effect
In mice treated with a combination of carbon ion beams and an immune checkpoint inhibitor, the lab showed that the treatment was also effective against tumors that were not irradiated (the abscopal effect). The lab is now examining other cancer types, with the aim of elucidating the mechanism.
*Illustrative imageRadiation response in pancreatic ductal cancer models
The lab has so far used a subcutaneous transplantation model of mouse pancreatic ductal cancer. Using a model that takes the tumor microenvironment into account, the lab is examining responses to radiation.
*Illustrative imageRelease of cancer antigens after radiation
The lab is modeling the process by which cancer antigens, which are information from cancer cells that is important for activating immunity against cancer, are released after irradiation.
*Illustrative imageRadiation-induced death of immune cells
Radiation can enhance immune responses against cancer. At the same time, the lab focuses on the phenomenon in which radiation kills immune cells.
MembersFaculty
The Radiation Therapy Biology Lab consists of faculty members; visiting professors, visiting faculty, and visiting researchers; doctoral, master's, and undergraduate students; and research students.
- ProfessorYutaka Takahashi
- Associate ProfessorKazumasa Minami
- Project Assistant ProfessorShohei Katsuki
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “Telescopic radiation shielded door” X Ray Doors / CC BY-SA 4.0 (cropped)
- Investigating the abscopal effect: “Varian-like Linear Accelerator for Precision Radiation Therapy” Bot1070 / CC0 (cropped)
- Radiation response in pancreatic ductal cancer models: “Cytology of pancreatic well-differentiated neuroendocrine tumor with salt-and-pepper chromatin, Pap stain” Mikael Häggström, M.D. Author info - Reusing images- Conflicts of interest: None Mikael Häggström, M.D.Consent note: Consent from the patient or patient's relatives is regarded as redundant, because of absence of identifiable features (List of HIPAA identifiers) in the media and case information (See also HIPAA case reports guidance). / CC0 (cropped)
- Release of cancer antigens after radiation: “Immune Cells (NIH BioArt 253)” Courtesy of NIAID Ryan Kissinger / Public domain (cropped)
- Radiation-induced death of immune cells: “Healthy Human T Cell” NIAID/NIH / Public domain (cropped)
- Related lab (Acute and Palliative Care Lab): “Patient lying in hospital bed in intensive care unit in Germany in 2015” Pittigrilli / CC BY-SA 4.0 (cropped)
- Related lab (Perioperative Management Lab): “AusMAT team members performing surgery ( )” Department of Foreign Affairs and Trade / CC BY 2.0 (cropped)
- Related lab (Psychiatric and Mental Health Nursing Lab): “Nursing staff, St Mary's Hospital” Ardosion / CC BY-SA 4.0 (cropped)
- Related lab (Chronic Illness Nursing Lab): “Nurse checks blood pressure” Linda Bartlett (Photographer) / Public domain (cropped)
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