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Pathological Ultrasound Medicine Lab
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The lab develops non-invasive diagnostic methods for digestive diseases using ultrasound.
AboutAbout the lab
Developing diagnostic methods for digestive diseases with ultrasound
The Pathological Ultrasound Medicine Lab aims to develop non-invasive tests (NITs) for digestive diseases using ultrasound.
The lab combines ultrasound with blood biomarkers to create more accurate diagnostic methods.
Clinical and basic research go hand in hand, with studies using animal models and human clinical data.
The lab welcomes students who work as radiologic technologists, who aim to join medical companies, or who want to become researchers or university faculty.
Key terms
- Non-invasive test (NIT)
- A method of examining disease without tests that damage the body, such as liver biopsy. It is called NIT, from the English initials of non-invasive test.
- Nonalcoholic fatty liver disease (NAFLD)
- A general term for fatty liver not caused by alcohol consumption. It is divided into non-progressive fatty liver and progressive steatohepatitis (NASH).
- Biomarker
- An indicator, measured in blood or other samples, that provides clues to the presence or progression of a disease.
- Glycan
- A chain-like biological substance, considered the third class after nucleic acids and proteins. It also plays important roles in metabolism and immunity.
NewsLab news
View More ↗ResearchResearch themes
As obesity increases, the lab aims to elucidate the pathology of digestive diseases, such as liver and pancreatic diseases, that are made worse by obesity, and to develop new diagnostic and treatment methods. Focusing on nonalcoholic fatty liver disease (NAFLD), the lab aims to develop diagnostic methods that combine ultrasound with blood biomarkers.
*Illustrative imageDeveloping NITs using ultrasound
Ultrasound can now be used to assess liver fibrosis, steatosis, and inflammation/necrosis. Using animal models and human clinical data, the lab is developing NITs based on ultrasound.
*Illustrative imageBasic research on the pathology of fatty liver
The lab investigates the pathology of NAFLD using genetically modified mice. Analysis of adiponectin-deficient mice revealed that adiponectin suppresses the progression of liver fibrosis and the development of liver cancer, and the lab also found that in mice that strongly express the glycosyltransferase GnT-V, the progression of NAFLD is markedly suppressed.
*Illustrative imageBlood biomarkers for fatty liver
The lab is searching for blood-based indicators that can diagnose NAFLD. Through work by the Miyoshi Lab in the Department of Health Sciences, fucosylated target protein Mac-2 binding protein and fucosylated haptoglobin were found to be useful biomarkers, and an NIT using a blood test that combines the two was developed.
*Illustrative imageToward diagnosis and treatment of digestive diseases
Using glycan analysis methods and ultrasound, the lab pursues research along two axes: developing new diagnostic methods using human blood and organ specimens, and elucidating disease pathology using genetically modified mice. The lab aims to apply the findings to large populations.
MembersFaculty
The Pathological Ultrasound Medicine Lab consists of faculty members and doctoral, master's, and undergraduate students.As of 2026
- ProfessorYoshihiro Kamada
- Assistant ProfessorTakashi Hashido
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “Scanning machine” Salaha mahmood / CC0 (cropped)
- Developing NITs using ultrasound: “Liver Transient Elastography (FibroScan) result showing Liver Stiffness Measurement (LSM) and Controlled Attenuation Parameter (CAP)” Goleisureintl / CC BY 4.0 (cropped)
- Basic research on the pathology of fatty liver: “Liver steatosis fatty change” Laboratory of Experimental Pathology, Division of Intramural Research, NIEHS (NIH) / Public domain (cropped)
- Blood biomarkers for fatty liver: “Blood test samples” Fumikas Sagisavas / CC0 (cropped)
- Toward diagnosis and treatment of digestive diseases: “A modern medical ultrasound scanner” Harrison Keely / CC BY 4.0 (cropped)
- Related lab (Acute and Palliative Care Lab): “Patient lying in hospital bed in intensive care unit in Germany in 2015” Pittigrilli / CC BY-SA 4.0 (cropped)
- Related lab (Perioperative Management Lab): “AusMAT team members performing surgery ( )” Department of Foreign Affairs and Trade / CC BY 2.0 (cropped)
- Related lab (Psychiatric and Mental Health Nursing Lab): “Nursing staff, St Mary's Hospital” Ardosion / CC BY-SA 4.0 (cropped)
- Related lab (Chronic Illness Nursing Lab): “Nurse checks blood pressure” Linda Bartlett (Photographer) / Public domain (cropped)
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