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Cancer Vaccine Therapy Lab
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A lab that studies cancer vaccines targeting WT1, from basic research through clinical studies.
AboutAbout the lab
Cancer vaccines, from basic research to the clinic.
The Cancer Vaccine Therapy Lab studies cancer vaccines that target WT1, a tumor antigen produced in large amounts in most types of human tumors.
Cancer-specific immunotherapy is a field attracting attention as a treatment alongside surgery, radiation, and chemotherapy.
The lab's distinguishing feature is that it can carry out everything from basic research to clinical research in the field of tumor immunotherapy.
The lab is established as an endowed department of the Graduate School of Medicine.
Key terms
- WT1 peptide vaccine
- A cancer vaccine that administers part (a peptide) of the tumor antigen WT1 to elicit an immune response against tumors expressing WT1
- T cell receptor (TCR)
- The receptor T cells use to recognize antigens. This lab isolates it from WT1-responsive T cells and examines it
- Avidity
- The total binding strength between an antigen and an antibody. Here it refers to differences in the strength of binding between the TCR and the WT1/HLA complex
ResearchResearch themes
The Cancer Vaccine Therapy Lab develops WT1 peptide vaccines that target WT1, which is produced in large amounts in most types of human tumors, and carries the work from basic research through clinical research. The research introduction on the lab website dates from around 2017, and the themes below reflect that content.
*Illustrative imageCombination Therapy for Newly Diagnosed Malignant Glioma
The lab conducted a phase I clinical trial in which patients with newly diagnosed malignant glioma received a WT1 peptide vaccine together with temozolomide, after treatment with radiation and temozolomide. The results showed that it is a promising treatment compared with standard therapy.
*Illustrative imageCocktail Vaccine for Recurrent Disease
The lab conducted a clinical trial of a cocktail vaccine combining WT1 killer peptides and helper peptides in recurrent malignant glioma. In addition to WT1-responsive CD8-positive T cells, CD4-positive T cells were strongly induced, and the immune response lasted for a long time.
*Illustrative imageDirect Antitumor Activity of CD4-Positive T Cells
The lab isolated T cell receptors (TCRs) from WT1-responsive CD4-positive T cells, introduced them into CD4-positive T cells, and examined them. The cells were found to damage WT1-expressing tumor cells, showing that they have direct antitumor activity.
*Illustrative imageT Cell Memory Formation and TCR Differences
The lab isolated multiple TCRs from WT1-responsive CD8-positive T cells. It showed that differences in the avidity between the TCR and the WT1/HLA complex change how T cells differentiate, including how readily they become memory T cells.
MembersFaculty
- Associate Professor, Endowed ChairFumihiro Fujiki
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “Nurse administers a vaccine (1)” Rhoda Baer (Photographer) / Public domain (cropped)
- Combination Therapy for Newly Diagnosed Malignant Glioma: “Brain Tumor MRI” 作者不詳 / Public domain (cropped)
- Cocktail Vaccine for Recurrent Disease: “Smallpox vaccine” Photo Credit: James Gathany Content Providers(s): CDC / Public domain (cropped)
- Direct Antitumor Activity of CD4-Positive T Cells: “Activation of T and B cells” Immcarle105 / CC BY-SA 4.0 (cropped)
- T Cell Memory Formation and TCR Differences: “1FYT T-cell receptor and HLA class II complex” Takuma-sa / CC0 (cropped)
- Related lab (Disease Data Science Lab): “Cdnaarray” Mangapoco / CC BY 2.5 (cropped)
- Related lab (Drug Discovery Neuroscience Lab): “Drug discovery cycle 2” Boghog / CC BY-SA 4.0 (cropped)
- Related lab (Medical Data Science Lab): “Medical Data Collection and Screening - ATK Grassroots Development Programme - Kolkata” Biswarup Ganguly / CC BY 3.0 (cropped)
- Related lab (Gene and Stem Cell Regenerative Therapeutics Lab): “AA01946a” SozvezdieL / CC BY 4.0 (cropped)
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