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Neurosurgery Lab
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A lab that moves between clinical practice and research to tackle diseases of the brain and spinal cord.
AboutAbout the lab
Research with a clinical perspective, and clinical practice with a research perspective.
The Neurosurgery Lab treats patients with diseases of the brain and spinal cord, and also conducts research in neuroscience, stroke, neural regeneration, and brain tumors.
The lab's research is not limited to medicine, and it draws on collaboration with fields ranging from mathematical engineering to the humanities.
In recent years, alongside basic research, the lab has been active in clinical and translational research, aiming to bring its findings back to clinical practice.
The department was established in 1970, and its motto is "to provide advanced medical care across a wide range of fields."
Key terms
- Glioblastoma
- A type of brain tumor that is difficult to treat and intractable
- CAR-T cell therapy
- An immunotherapy in which T cells are engineered to recognize antigens on the surface of tumor cells and attack them
- PDX (patient-derived xenograft)
- An animal model that uses cultured cells derived from patient specimens
- Meningioma
- A type of benign brain tumor. It grows slowly, and surgery becomes necessary if it enlarges and compresses the brain
NewsLab news
A lab member received the Best Academic Research Award (Clinical Category) at the 41st Annual Meeting of the Japanese Society of Spinal Surgery
A lab member received the Academic Encouragement Award (Takaomi Taira Award) from the Japan Society for Stereotactic and Functional Neurosurgery
An Assistant Professor received the Best Poster Award at the 19th Asian Epilepsy Surgery Congress
ResearchResearch themes
The Neurosurgery Lab conducts research on brain tumors, cerebrovascular disease, spinal and spinal cord disease, and neurological function disorders. It aims to connect clinical needs with research seeds.
*Illustrative imageDevelopment of immune cell therapy for glioblastoma
The lab is developing CAR-T cell therapy and CAR-NK cell therapy for glioblastoma, an intractable brain tumor. In these therapies, T cells or NK cells are engineered to attack the tumor. The lab is working with the Department of Hematology and Oncology at the University of Osaka toward practical application.
*Illustrative imageResearch on malignant brain tumors using patient specimens
The lab establishes cultured cells from specimens collected during surgery and creates PDX (patient-derived xenograft) animal models. Using PDX, it clarifies the molecular biological mechanisms of malignant brain tumors and conducts research toward developing new treatments.
*Illustrative imageStudy of volume changes in meningioma
The lab studies meningioma, a slow-growing benign brain tumor. It examines the natural course of meningiomas under follow-up observation and conducts research to predict whether treatment will become necessary.
*Illustrative imageClinical trial of brain tumor treatment with focused ultrasound
In this clinical trial, the ExAblate 4000 Type 2 focused ultrasound system is applied to brain tumor treatment, delivering low-frequency focused ultrasound while microbubbles are administered. It is the first attempt in Japan to use focused ultrasound for brain tumors, and enrollment has now closed.
MembersFaculty
The members of the Neurosurgery Lab consist of faculty, research-focused faculty and researchers, hospital staff physicians, doctoral students, international students, clinical professors, project researchers, and visiting faculty.As of 2024
- ProfessorHaruhiko Kishima
- Project ProfessorMasayuki Hirata
- Hospital Professor, Associate ProfessorSatoru Oshino
- LecturerHajime Nakamura
- LecturerNaoki Tani
- Project LecturerKoichi Hosomi
- Assistant ProfessorNoriyuki Kijima
- Assistant ProfessorMasahisa Takagaki
- Assistant ProfessorKoji Ninomiya
- ProfessorTakufumi Yanagisawa
- Assistant ProfessorWui Min Khoo
- Project Assistant ProfessorTomohiko Ozaki
- Assistant ProfessorRyuichi Hirayama
- Project Assistant ProfessorChisato Yokota
- Project Assistant ProfessorTakeshi Shimizu
- Project Assistant ProfessorToru Umehara
- Project LecturerRyohei Fukuma
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “Breast Surgery Procedure in Modern Operating Room” Tyler Frew MD / CC BY-SA 4.0 (cropped)
- Development of immune cell therapy for glioblastoma: “Glioblastoma brain infiltration zone” Jensflorian / CC BY-SA 3.0 (cropped)
- Research on malignant brain tumors using patient specimens: “Brain Tumor on Brain Slice ( )” National Center for Advancing Translational Sciences from Bethesda, MD / Public domain (cropped)
- Study of volume changes in meningioma: “Meningioma of the sagittal sinus isolated” RASPBERRY VIBE / CC0 (cropped)
- Clinical trial of brain tumor treatment with focused ultrasound: “Định vị và chuẩn bị bệnh nhân MRI HIFU” Bác sĩ Nguyễn Minh Đức / CC BY-SA 4.0 (cropped)
- Related lab (Gastroenterological Surgery II Lab): “AfS surgical team at the operating room” Almondbite3 / CC BY-SA 4.0 (cropped)
- Related lab (Ophthalmology Lab): “Slit lamp eye examination” OKJaguar / CC BY-SA 4.0 (cropped)
- Related lab (Thoracic Surgery Lab): “Antique surgical instruments, AM Epidauros, 091145” Zde / CC BY-SA 4.0 (cropped)
- Related lab (Neurology Lab): “Neuron (100x magnification)” Ns takes photos / CC BY 4.0 (cropped)
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