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Life Chemical Biology Lab
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The lab develops vaccine materials by drawing on the characteristics of mucosal immunity.
AboutAbout the lab
Developing vaccine materials from the characteristics of mucosal immunity
The Vaccine Materials Project focuses on the unique characteristics of mucosal immunity and conducts research that leads to the development of mucosal vaccines and immunotherapies.
Mucosal vaccines delivered by inhalation or orally have been put into practical use for some infectious diseases. Extending them to many other infectious diseases and allergies requires developing vaccine materials such as vaccine delivery systems and adjuvants.
Project Leader Jun Kunisawa also serves as a Visiting Professor in the cooperative graduate school program of the Graduate School of Science, The University of Osaka.
The lab's website presents it under the name "Vaccine Materials Project."
Key terms
- Mucosal immunity
- The immune system that protects the body at mucosal tissues. It is the foundation for developing mucosal vaccines.
- Adjuvant
- A substance used together with a vaccine to enhance the immune response.
- DDS (drug delivery system)
- Technology for delivering the components of a drug or vaccine to a target site in the body.
ResearchResearch themes
The lab pursues basic immunology research that focuses on the unique characteristics of mucosal immunity, and builds on those findings to develop mucosal vaccines and immunotherapies. By developing vaccine materials based on the specificity of mucosal immunity and on immune regulation through gut environmental factors, it is working on next-generation vaccines and diagnostics for various infectious diseases and allergic and inflammatory diseases.
*Illustrative imageCreating materials for mucosal vaccines
The lab focuses on dietary components with immune-modulating activity, such as lipids, vitamins, and herbal medicine ingredients, and applies their metabolites and structural analogs to vaccines. It also investigates how gut bacteria and probiotic bacteria enhance vaccine effects.
*Illustrative imageApplying the features of mucosal immunity to new vaccines
The lab studies the functions specific to mucosal immunity and uses them to develop new mucosal vaccines. Its work includes vaccines that use the mechanisms of differentiation and induction of IgA-producing cells, a safety evaluation system based on an antibody library that can identify mast cells, and applications to drug delivery systems (DDS).
MembersFaculty
The Vaccine Materials Project members consist of the Project Leader, researchers, JSPS Research Fellows, Project Researchers, cooperative graduate school students, research coordination specialists, technical assistants, administrative assistants, Visiting Researchers, Collaborating Researchers, and trainees.As of 2026
- Visiting ProfessorJun Kunisawa
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “COVID-19 vaccine vial AstraZenaca 2021 (UK)” Whispyhistory / CC BY-SA 4.0 (cropped)
- Creating materials for mucosal vaccines: “B vitamin supplement tablets” Ragesoss / CC BY-SA 3.0 (cropped)
- Applying the features of mucosal immunity to new vaccines: “Vero Cell COVID-19 vaccine vial, cotton swab and syringe” Ajay Kumar Chaurasiya / CC BY-SA 4.0 (cropped)
- Related lab (Kansai Center Materials Chemistry (AIST) Lab): “SiSic beam” Hshkrc / CC BY-SA 4.0 (cropped)
- Related lab (Peptide Institute Lab): “Solid Peptide Synthesis reactor” Rudyher27 / CC BY-SA 4.0 (cropped)
- Related lab (Kansai Center Materials and Chemistry Area Research Institute for Materials Fundamentals Photofunctional Materials Emergence Group (AIST) Lab): “Nd laser VisNatural” FDominec / CC BY-SA 3.0 (cropped)
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