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Peptide Institute Lab
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The lab chemically synthesizes proteins and peptides.
AboutAbout the lab
Chemically synthesizing peptides to explore how they work
The lab develops methods for synthesizing proteins, peptides, and glycoconjugates, and studies their physiological functions.
Based on solution-phase chemical synthesis, the lab also develops protecting groups and solvent systems that make intermediates formed during synthesis more soluble.
The synthesized samples are used in joint research with researchers in Japan and abroad to investigate the mechanisms by which bioactivity arises.
The Department of Chemistry, Graduate School of Science, The University of Osaka lists the lab as a collaborative, concurrent-appointment chair.
Key terms
- Solution-phase synthesis
- One method of chemical synthesis for building peptides and proteins by linking amino acids together. The reactions proceed in solution.
- Protecting group
- A group of atoms that temporarily covers and protects a part of a molecule that should not react during synthesis.
- Structure-activity relationship
- The relationship between differences in a compound's structure and the strength of its biological activity.
ResearchResearch themes
The lab develops methods for synthesizing proteins, peptides, and glycoconjugates, with the aim of elucidating their physiological functions. Its research covers everything from developing synthetic methods to evaluating the functions of the resulting samples.
*Illustrative imageChemical synthesis and structure of proteins
The lab chemically synthesizes proteins and investigates the relationship between their functions and their secondary and tertiary structures.
*Illustrative imageDeveloping synthetic methods for glycopeptides
The lab develops methods for synthesizing conjugated peptides to which glycans and similar groups are attached, and evaluates their functions.
*Illustrative imageSynthesis of natural bioactive peptides
For natural bioactive peptides with clear physiological effects, the lab studies chemical synthesis methods and structure-activity relationships.
MembersFaculty
- Visiting ProfessorTatsuya Inui
- Visiting ProfessorTaku Yoshiya
- Visiting ProfessorToshihiro Yamamoto
VoicesStudent voices
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “Solid Peptide Synthesis reactor” Rudyher27 / CC BY-SA 4.0 (cropped)
- Chemical synthesis and structure of proteins: “Protein Structure of human NDNF” Alpha Fold Team / CC BY 4.0 (cropped)
- Developing synthetic methods for glycopeptides: “Glycan Tetrapeptide” GregorMonkey / CC BY-SA 4.0 (cropped)
- Synthesis of natural bioactive peptides: “1IGL Insulin-Like Growth Factor Ii 03” Nevit Dilmen / CC BY-SA 3.0 (cropped)
- Related lab (関西センター 材料化学
（産業技術総合研究所） ): “SiSic beam” Hshkrc / CC BY-SA 4.0 (cropped) - Related lab (生命ケミカルバイオロジー（医薬基盤・健康・栄養研究所）
): “COVID-19 vaccine vial AstraZenaca 2021 (UK)” Whispyhistory / CC BY-SA 4.0 (cropped) - Related lab (関西センター 材料・化学領域 材料基盤研究部門 光機能材料創発グループ（産業技術総合研究所）
): “Nd laser VisNatural” FDominec / CC BY-SA 3.0 (cropped)
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