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Organic and Biological Chemistry Lab
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A lab that chemically synthesizes proteins carrying glycans and studies what the glycans do.

AboutAbout the lab
Precisely synthesizing glycan-bearing proteins.
The lab precisely synthesizes proteins with attached glycans (glycoproteins) and investigates what roles glycans play on proteins.
Glycans attached to proteins vary in structure, so it is not easy to study the function of each individual glycan.
To address this, the lab chemically synthesizes glycoproteins with uniform glycan structures.
On the lab's website, it is introduced under the name "Kajihara Laboratory."
Key terms
- Glycan
- A molecule made of many sugars linked together. It binds to proteins and is involved in their function.
- Glycoprotein
- A protein with glycans attached. It is found on cell surfaces and in body fluids.
- Native chemical ligation
- A reaction that selectively joins unprotected peptide fragments. It is used to assemble proteins by chemical synthesis.
NewsLab news
A paper by Assistant Professor Hirao et al. was published in Current opinion in chemical biology
A doctoral student received a Student Presentation Award at the Spring Annual Meeting of the Chemical Society of Japan
A doctoral student received the Best Discussion Award at a symposium of the Suntory Foundation for Life Sciences
A paper by Professor Kajihara et al. was published in Angewandte Chemie (International ed. in English)
A paper by Professor Kajihara et al. was published in Angewandte Chemie International Edition
ResearchResearch themes
To clarify how glycans function on proteins, the lab synthesizes glycan-bearing proteins in homogeneous form. Using the synthesized glycoproteins, it investigates the functions of glycans on proteins.
View More ↗MembersFaculty
The members of the Organic and Biological Chemistry Lab consist of faculty, a Project Professor, students in the doctoral, master's, and undergraduate programs, and secretaries.As of 2025
- ProfessorYasuhiro Kajihara
- LecturerYuta Maki
- Assistant ProfessorKohtaro Hirao
- Assistant ProfessorHersa Milawati
VoicesStudent voices
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “Structural model of SARS-CoV-2 infection - Oo 422117” Victor Padilla-Sanchez / CC BY 4.0 (cropped)
- Synthesis of Glycoproteins with Uniform Glycans: “Mucin” Jcastr07 / CC BY-SA 4.0 (cropped)
- Related lab (Natural Products Organic Chemistry Lab): “Gram negative cell wall-id” Gram_negative_cell_wall.svg: Jeff Dahl derivative work: 24Adrianus (talk) / CC BY-SA 3.0 (cropped)
- Related lab (Polymer Reaction Chemistry Lab): “Polypropylene Pellets - DPLA - f7c2fa29d14525ce21219452f4a1a316” Quantum Chemical Corporation / CC BY 4.0 (cropped)
- Related lab (Biophysical Chemistry Lab): “AP5M1 3D Protein Structure” Tobithias / CC BY-SA 4.0 (cropped)
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