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Ubiquitin Biology Lab
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The lab explores the mechanisms of inflammation and cell death through the functions of ubiquitin.
AboutAbout the lab
Elucidating the fundamental principles of the ubiquitin system
The lab focuses on ubiquitin, a molecule that carries out post-translational modification.
Ubiquitin is involved in every kind of biological effect, and when the ubiquitin system breaks down, it can trigger diseases such as cancer, autoimmune diseases, and neurodegenerative diseases.
By understanding the fundamental principles of the ubiquitin system, the lab aims to approach the mechanisms by which many diseases arise.
In particular, the lab focuses on linear ubiquitin chains generated by LUBAC.
Key terms
- Ubiquitin
- A molecule that carries out post-translational modification. It has been found to modify molecules other than proteins as well
- Post-translational modification
- A modification that occurs after a protein is made, such as when another molecule attaches to it
- LUBAC
- A complex that generates linear ubiquitin chains
- Linear ubiquitin chain
- A chain in which two ubiquitin molecules are joined by a special type of linkage. It has important functions in inflammation and cell death
ResearchResearch themes
The lab focuses on ubiquitin, which carries out post-translational modification, and aims to elucidate the fundamental principles of the ubiquitin system that controls every kind of biological function. Its ultimate goal is to approach the mechanisms by which many diseases arise.
*Illustrative imageFundamental principles of the ubiquitin system
Ubiquitin creates a wide variety of codes to control biological effects, but the mechanisms of action of the enzymes that generate these codes are also complex and remain poorly understood. The lab aims to understand these fundamental principles.
*Illustrative imageLinear ubiquitin chains, inflammation, and cell death
The lab pays particular attention to linear ubiquitin chains generated by LUBAC. These are chains in which two ubiquitin molecules are joined by a special type of linkage, and they have important functions in inflammation and cell death.
*Illustrative imageUbiquitin modification of non-protein substrates
It has recently become clear that molecules other than proteins are also modified by ubiquitin. The lab is expanding its research by focusing on the regulatory mechanisms and roles of this modification.
MembersFaculty
The lab's members are faculty, technical assistants, and secretaries.
- ProfessorFumiyo Ikeda
- Associate ProfessorKota Yanagitani
- Assistant ProfessorSoshiro Kashio
VoicesStudent voices
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “Ubiquitin cartoon-2” Rogerdodd / CC BY-SA 3.0 (cropped)
- Fundamental principles of the ubiquitin system: “Proteaosome 1fnt side” Thomas Splettstoesser (www.scistyle.com) / CC BY-SA 3.0 (cropped)
- Linear ubiquitin chains, inflammation, and cell death: “Ribbon view of the Orange Carotenoid Protein Structure 1M98” . The original uploader was Melnicki at English Wikipedia. / CC BY-SA 4.0 (cropped)
- Ubiquitin modification of non-protein substrates: “Ubiquitin cartoon” en:User:Rogerdodd / Public domain (cropped)
- Related lab (Brain Engineering Lab): “A segment of pyramidal cell dendrite from stratum radiatum (CA1)” Dr. Kristen M. Harris / CC BY 2.0 (cropped)
- Related lab (Biofunctional Molecular Measurement Lab): “Fluorecence Microscope-Köhler-Zeiss-1908” Carl Zeiss AG / Public domain (cropped)
- Related lab (Human Evolution and Functional Genomics Lab): “Primate skull series with legend cropped-ar” Primate_skull_series_with_legend_cropped.png: *Primate_skull_series_with_legend.png: Christopher Walsh, Harvard Medical School derivative work: Gary2863 (talk) derivative work: باسم / CC BY 2.5 (cropped)
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