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Biofunctional Molecular Measurement Lab
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The lab observes and measures biological phenomena at the single-molecule level.
AboutAbout the lab
Seeing and measuring life at the single-molecule level
The lab observes, manipulates, and measures biological phenomena at the single-molecule level in aqueous solution, keeping their function intact as much as possible.
The lab works on elucidating the rotation mechanism of the bacterial flagellar motor, the signal transduction mechanism of the bacterial chemotaxis system, and the working mechanism of actomyosin.
The lab's microscope systems are customized, and building the instruments is part of the research.
On the lab's website, it is presented under the name "Ishijima Lab."
Key terms
- Flagellar motor
- A rotating motility device found in bacteria
- Chemotaxis
- The mechanism by which bacteria change their direction of movement in response to their surrounding environment
- Actomyosin
- A combination of the motor proteins actin and myosin, in which myosin generates force (tension)
NewsLab news
A paper analyzing the chemotactic response of single E. coli cells was published online ahead of print in Biophysics and Physicobiology
A paper examining the relationship between CheY-P concentration and motor behavior in single E. coli cells was published in Science Advances
A paper simultaneously measuring the intracellular dynamics of CheB and motor rotation was published in Science Advances
ResearchResearch themes
The lab's policy is to observe, manipulate, and measure biological phenomena at the single-molecule level in aqueous solution, keeping their function intact as much as possible. Specific research themes are elucidating the rotation mechanism of the bacterial flagellar motor, the signal transduction mechanism of the bacterial chemotaxis system, and the working mechanism of actomyosin, as well as heat measurement of brown adipocytes and the development of a new measurement system using carbon nanotubes (CNTs).
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MembersFaculty
The Ishijima Lab consists of faculty members and master's students.As of 2026
- ProfessorAkihiko Ishijima
- Associate ProfessorHajime Fukuoka
- Assistant ProfessorYumiko Uchida
VoicesStudent voices
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “Fluorecence Microscope-Köhler-Zeiss-1908” Carl Zeiss AG / Public domain (cropped)
- Measuring biological phenomena at the single-molecule level: “Physical model of a bacterial flagellum” Alan Wolf / CC BY-SA 2.0 (cropped)
- Related lab (Ubiquitin Biology Lab): “Ubiquitin cartoon-2” Rogerdodd / CC BY-SA 3.0 (cropped)
- Related lab (Bioimaging Lab): “ZEISS LSM 800 with Airyscan- Your Compact Confocal Power Pack ( )” ZEISS Microscopy from Germany / CC BY-SA 2.0 (cropped)
- Related lab (Perceptual and Cognitive Neuroscience Lab): “FEAT” Bravegirl2003 / CC BY-SA 3.0 (cropped)
- Related lab (Fluid Engineering Lab): “Columinar thermal convection in a rotating sphere” Cardinphilippe / CC BY-SA 4.0 (cropped)
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