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Bioprocess Systems Engineering Lab
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The lab studies manufacturing technologies for cells and tissues aimed at regenerative medicine.
AboutAbout the lab
Building technologies to understand and nurture human tissue
The Bioprocess Systems Engineering Lab studies technologies for producing cell and tissue products in the fields of regenerative medicine, tissue engineering, and drug discovery.
Focusing on biological reaction elements such as enzymes and on reaction environments such as cells and tissues, the lab aims to solve health and medical problems by harnessing the power of living organisms.
For new industrial fields built on cell manufacturing, the lab aims to practice 'Koto-zukuri', an approach made up of nurturing people, making products, and creating rules, and to contribute to starting new industries through a three-way partnership of industry, government, and academia.
Through research and team building, the lab aims for students to acquire knowledge of biochemical engineering and the ability to take action.
Key terms
- Koto-zukuri
- An approach to starting new industries, made up of three elements: nurturing people (hito-zukuri), making products (mono-zukuri), and creating rules (rule-making)
- Multiscale
- A perspective that examines biological reactions at different levels of size: single cells, cell aggregates, tissues, and organs
- Cell aggregate
- A cluster of cells that forms the smallest unit in which cells can exchange information with one another
ResearchResearch themes
Aiming to understand how human tissue forms and to build technologies that nurture it, the lab studies manufacturing technologies for cells and tissues for regenerative medicine, and is also extending this work to drug discovery screening technologies. It also works on establishing process control centered on cell culture and quality control methods for cell and tissue products.
*Illustrative imageHuman Tissue Formation and Production of Regenerative Medicine Products
The lab views production processes that use human tissue as heterogeneous biological reactions that change over time and space, and analyzes them at multiple scales, from single cells to organs. It first examines cell-to-cell signaling in cell aggregates, aiming to clarify the mechanisms by which tissue forms and to establish methods for process control and quality control of regenerative medicine products.
*Illustrative imageCulture Processes That Control Cell Behavior
The lab has worked on controlling cell behavior and developing culture processes based on that control. It has a track record in culturing various differentiated cells, mesenchymal stem cells, and induced pluripotent stem cells. Based on the concept of the 'Waddington landscape', it has identified tools for producing cell tissues with desired structures and functions, and has proposed blueprints for culture processes.
MembersFaculty
The members of the Bioprocess Systems Engineering Lab consist of faculty members, visiting faculty, project researchers, researchers in joint research chairs, project administrative staff, administrative assistants, dispatched staff, students in the doctoral program, master's program, and undergraduate program, and research students.As of 2026
- ProfessorMasahiro Kino-Oka
- Associate ProfessorMee-Hae Kim
- Assistant ProfessorRiku Yamamoto
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “Line of culture flask ( )” Jean-Etienne Minh-Duy Poirrier from USA / CC BY-SA 2.0 (cropped)
- Human Tissue Formation and Production of Regenerative Medicine Products: “Binder CB 210 incubator interior” Shinryuu / Public domain (cropped)
- Culture Processes That Control Cell Behavior: “Bioreactor for cell culture in the laboratory” Habin Zhang / CC BY-SA 4.0 (cropped)
- Related lab (Biomaterials Chemistry Lab): “Nanofibrillar cellulose hydrogel” Qspheroid4 / CC BY-SA 4.0 (cropped)
- Related lab (Chemical Biology Lab): “Fluorescence microscopy with ZEISS Axiocam (cropped)” ZEISS Microscopy / CC BY-SA 2.0 (cropped)
- Related lab (Biochemical Engineering Lab): “Wine fermentation tanks in a winery in Tarija” Aldrihe / CC BY-SA 4.0 (cropped)
- Related lab (Mathematical Systems Science Lab [Graduate School of Information Science and Technology]): “Frank-Wolfe Algorithm” Stephanie Stutz / CC BY 4.0 (cropped)
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