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Molecular Systems Creation Chemistry Lab (Yamaguchi Lab) [Institute of Scientific and Industrial Research]
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The lab uses synthetic organic chemistry to create molecular systems that control and visualize biomolecules and cells.

AboutAbout the lab
Creating new molecular systems to obtain previously unknown biological information.
The Molecular Systems Creation Chemistry Lab (Yamaguchi Lab) uses synthetic organic chemistry to create new molecular systems for obtaining biological information that could not be obtained before.
The lab produces synthetic molecules with desired functions and develops systems that control or visualize biomolecules and cells.
The developed molecular systems serve as platform technologies for solving a wide range of problems, from regenerative medicine, drug discovery, and diagnostics to useful-substance production and biosensors, and the lab conducts applied research on them with collaborators in Japan and abroad.
The lab is one of the labs where undergraduates in the School of Science, Department of Chemistry can be assigned for their graduation research, and from FY2026 it also accepts undergraduates in the Biotechnology course of the School of Engineering, Department of Applied Science.
Key terms
- Regenerative medicine
- Medicine, actively studied since the discovery of iPS cells, in which cells with desired functions are administered as drugs or artificial tissues
- Light-responsive cell-attachment surface
- The surface of a culture dish or similar item on which cells attach or stop attaching when exposed to light
- Cell array
- Cells arranged at high density, allowing many single cells to be observed under a microscope
ResearchResearch themes
Based on synthetic organic chemistry, the lab creates molecular systems that control, visualize, and produce biomolecules and cells. Using the developed molecular systems, it tackles a wide range of problems, from medicine to food and the environment.
*Illustrative imageCulture surfaces that attach and detach cells with light
The lab modifies substrates with original polymer materials designed and synthesized using photochemistry, and develops culture surfaces on which cells attach or detach instantly in response to light. It is developing technologies to arrange cells freely and to remove them selectively.
*Illustrative imageLight-responsive single-cell array technology
Using light-responsive cell-attachment surfaces, the lab creates cell arrays in which a desired number of cells are placed at each position, and observes the behavior of many single cells and interactions between cells at large scale under a microscope. It is also researching, toward medical applications, technology for examining interactions between immune cells and cancer cells at the single-cell level.
MembersFaculty
The members of the Yamaguchi Lab consist of faculty, Invited Professors, project researchers, and PhD, master's, and undergraduate students.As of 2026
- ProfessorSatoshi Yamaguchi
- Associate ProfessorShinya Yamahira
- Assistant ProfessorHao Zhu
- Project Assistant ProfessorYoko Futaki
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “Digestion of a sample (Alessandri 1895.29)” valeg96 / Public domain (cropped)
- Culture surfaces that attach and detach cells with light: “Cell Culture in a tiny Petri dish” kaibara87 / CC BY 2.0 (cropped)
- Light-responsive single-cell array technology: “Microtiter plate” Jeffrey M. Vinocur / CC BY 2.5 (cropped)
- Related lab (Nanophotonics Lab): “InVia Raman microscope - March 2008” theterrifictc / CC BY-SA 2.0 (cropped)
- Related lab (Structural Organic Chemistry Lab): “Chemistry Experiment 3D” TeWeBs / CC BY-SA 4.0 (cropped)
- Related lab (Physical Organic Chemistry Lab): “Sumanene-3D-balls” Jynto (talk) / CC0 (cropped)
- Related lab (Bio-Information Measurement Lab [Graduate School of Information Science and Technology]): “Thermo - Finnigan LCQ Mass Spectrometer ( )” Kitmondo Marketplace / CC BY 2.0 (cropped)
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