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Cell Biology of Energy Conversion Lab
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A lab that uses yeast to uncover how cells sense and respond to stress.
AboutAbout the lab
Exploring cellular stress responses through yeast.
The lab uses yeast as its main model organism to study how signals from cellular metabolites are transmitted and how cells respond to various stresses.
Using genetic and biochemical methods, the lab investigates transcription factors that sense stress and activate the necessary genes, as well as the mechanisms that transmit signals within cells.
Undergraduates are assigned to the lab in their fourth year (graduate school: Division of Applied Life Sciences, Graduate School of Agriculture).
Key terms
- Glycolysis
- A metabolic pathway common to living things that breaks down sugar to extract energy
- Transcription factor
- A protein that binds to DNA and regulates which genes are turned on
ResearchResearch themes
Using yeast, the lab studies with genetic and biochemical methods how metabolites inside the cell and stress on the membrane and cell wall are transmitted as signals and determine the cell's response.
*Illustrative imageMethylglyoxal and cell division
The lab has shown in yeast that methylglyoxal, a metabolite produced by glycolysis, activates the DNA damage signaling pathway and disrupts the asymmetric localization of Kar9, a protein that determines the direction in which the nucleus divides.
*Illustrative imageCell wall stress and membrane signaling
The lab has shown in yeast that the TORC2 signaling pathway, which maintains the state of the plasma membrane, is suppressed by the pathway that protects the cell wall. This is thought to be a mechanism for responding appropriately when the cell wall is damaged.
MembersFaculty
The members of the Cell Biology of Energy Conversion Lab consist of faculty, technical assistants, and master's and undergraduate students.
- ProfessorYoshiharu Inoe
VoicesStudent voices
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “Budding yeast cell walls model. 3D printed” Rosser1954 / CC BY-SA 4.0 (cropped)
- Methylglyoxal and cell division: “Gram positive yeast cells in Gram staining of culture” Ajay Kumar Chaurasiya / CC BY-SA 4.0 (cropped)
- Cell wall stress and membrane signaling: “Yeast Cell Diagram Illustration” Morganocyte / CC BY-SA 4.0 (cropped)
- Related lab (Molecular Cell Breeding (Totipotency Regulation) Lab): “Transplanting rice seedlings Bali” John Y. Can / CC BY 2.0 (cropped)
- Related lab (Plant Nutrition Lab): “Листочок моху під мікроскопом” Andrei Savitsky / CC BY-SA 4.0 (cropped)
- Related lab (Plant Molecular Biology (Gene Function and Expression) Lab): “Marchantia polymorpha HC1” Holger Casselmann / CC BY-SA 3.0 (cropped)
- Related lab (Fermentation Control Lab): “Malaria Fermenter ( )” NIAID / CC BY 2.0 (cropped)
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