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Fermentation Control Lab
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The lab uses the power of microorganisms that consume methanol and methane to take on manufacturing, higher crop yields, and measures against global warming.
AboutAbout the lab
Drawing out the power of microorganisms that use methane and methanol.
The lab studies microorganisms that use one-carbon compounds (C1 compounds) such as methanol and methane, known as C1 microorganisms.
With molecules, chemistry, cells, and metabolism as keywords, the lab seeks to understand microbial metabolism and cellular mechanisms and to apply that understanding to protein production, higher crop yields, and reduction of greenhouse gases.
Prof. Yurimoto joined the lab in April 2025.
Undergraduate students join the lab in their fourth year (graduate school: Division of Applied Life Sciences, Graduate School of Agriculture).
Key terms
- C1 microorganisms
- Microorganisms that grow by feeding on one-carbon compounds such as methanol and methane.
- Methanotrophic bacteria
- Bacteria that grow by feeding on methane.
- Gene expression
- The process by which proteins are made in a cell based on the information in a gene.
ResearchResearch themes
The lab clarifies, at the molecular level, the metabolism and cellular mechanisms of C1 microorganisms that use methanol and methane, and aims to apply them to protein production, higher crop yields, reduction of greenhouse gases, and manufacturing from methane.
*Illustrative imageHow yeast works on methanol
Methylotrophic yeasts discovered at Kyoto University are used worldwide to produce proteins with genes that are highly active on methanol. The lab investigates how this strong gene expression is regulated, and links the findings to more efficient production.
*Illustrative imageIncreasing crops with microorganisms that live on leaves
Many methanol-utilizing bacteria live on leaf surfaces. The lab has clarified how these bacteria colonize leaves and succeeded in developing a technology that increases rice yield when the bacteria are sprayed on leaves. It is now working to elucidate how the yield increase occurs.
*Illustrative imageMethane produced by plants and microorganisms
How plants emit methane, and how microorganisms on leaves are involved, remains unknown. Alongside investigating these mechanisms, the lab is developing a technology that reduces methane emissions using methanotrophic bacteria that live on leaves.
*Illustrative imageMaking products from methane
The lab proposes the "C1 chem-bioeconomy," which uses methane and methanol as raw materials for manufacturing with microorganisms that have a low environmental impact. It is clarifying how bacteria oxidize methane and developing methods that use methane directly as a raw material.
MembersFaculty
Members of the lab include faculty, researchers, administrative assistants, and doctoral, master's, and undergraduate students.
- ProfessorHiroya Yurimoto
- Assistant ProfessorKosuke Shiraisi
VoicesStudent voices
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “Malaria Fermenter ( )” NIAID / CC BY 2.0 (cropped)
- How yeast works on methanol: “Methylobacterium symbioticum” Symborg / CC BY-SA 4.0 (cropped)
- Increasing crops with microorganisms that live on leaves: “Dendroseris litoralis spotted leaf vein Kew” Flobbadob / CC BY-SA 4.0 (cropped)
- Methane produced by plants and microorganisms: “Water reflection of a wooden house surrounded by trees with farmers walking in the paddy fields of Vang Vieng Laos” Basile Morin / CC BY-SA 4.0 (cropped)
- Making products from methane: “Shirley Chisholm State Park td ( - Penn Pier, Penn Flare” Tdorante10 / CC BY-SA 4.0 (cropped)
- Related lab (Plant Molecular Biology (Gene Function and Expression) Lab): “Marchantia polymorpha HC1” Holger Casselmann / CC BY-SA 3.0 (cropped)
- Related lab (Chemical Regulation of Biological Functions Lab): “Auxin Phototropism” Patricklockwoood / CC BY-SA 4.0 (cropped)
- Related lab (Cell Biology of Energy Conversion Lab): “Budding yeast cell walls model. 3D printed” Rosser1954 / CC BY-SA 4.0 (cropped)
- Related lab (Plant Nutrition Lab): “Листочок моху під мікроскопом” Andrei Savitsky / CC BY-SA 4.0 (cropped)
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