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Hepato-Pancreato-Biliary Surgery and Transplantation Lab
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The lab advances surgery and transplantation of the liver, biliary tract, and pancreas through regenerative medicine and medical-engineering collaboration.
AboutAbout the lab
Supporting patients' hope with knowledge, skill, and heart.
The lab provides surgery and multidisciplinary cancer treatment for diseases of the liver, biliary tract, and pancreas.
The lab performs minimally invasive treatment such as laparoscopic surgery and robot-assisted surgery, and in liver transplantation it carries out many transplants for end-stage liver disease and liver cancer.
With a view to returning results to the clinic, the lab conducts wide-ranging research on hepato-pancreato-biliary cancer and on regenerative and transplant medicine, and aims to train surgeons who can understand cutting-edge basic research.
The lab hosts an endowed department, the Department of Gastrointestinal Oncology Control and Organ Regeneration Surgery.
Key terms
- Decellularization
- Removing the cells from an organ and leaving only its framework, which is used as a scaffold for growing new cells
- Islet transplantation
- A treatment in which islets, clusters of insulin-producing cells in the pancreas, are isolated and transplanted
- Immune tolerance
- A state in which the immune system no longer attacks a transplanted organ or similar tissue
ResearchResearch themes
The lab conducts research in hepato-pancreato-biliary oncology and in regenerative and transplant medicine, with the aim of returning results to clinical practice.
*Illustrative imageLiver and biliary diseases and regenerative medicine
The lab develops new biliary reconstruction methods using artificial materials, creates transplantable artificial livers and small intestines from decellularized organs, and studies genomic analysis of liver cancer, liver injury caused by chemotherapy, and the cells involved in liver fibrosis and regeneration.
*Illustrative imagePancreatic surgery and islet transplantation
The lab studies the mechanisms by which pancreatic fluid leakage after pancreatic surgery becomes severe, and develops methods for isolating, preserving, and transplanting islets for islet transplantation.
*Illustrative imageResearch to improve liver transplantation
The lab works on elucidating the mechanisms of immune tolerance to transplanted livers, suppressing complement activity to reduce damage to transplanted organs, developing new organ preservation methods, and overcoming the problem of grafts that are too small.
*Illustrative imageDeveloping surgical devices through medical-engineering collaboration
Through collaboration between medicine and engineering, the lab develops medical devices that enable real-time fluorescence navigation during surgery.
MembersFaculty
- ProfessorEtsuro Hatano
- Associate ProfessorTakashi Ito
- Program-Specific Associate ProfessorTakamichi Ishii
- LecturerYoichiro Uchida
- LecturerKazuyuki Nagai
- LecturerSatoshi Ogiso
- Assistant ProfessorTakahiro Nishio
- Assistant ProfessorHiroto Nishino
- Assistant ProfessorTomoaki Yoh
- Program-Specific Hospital Assistant ProfessorHirofumi Hirao
- Program-Specific Hospital Assistant ProfessorHidenobu Kojima
- Program-Specific Assistant ProfessorKei Yamane
- LecturerTatsuya Okamoto
- Assistant ProfessorShinya Okumura
- Assistant ProfessorKatsunori Sakamoto
- Program-Specific Hospital Assistant ProfessorElena Sachie Kanbayashi
- Clinical Assistant ProfessorAsahi Sato
- Assistant ProfessorMasashi Kadohisa
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “Laparoscopic stomach surgery” Samuel Bendet, US Air Force / Public domain (cropped)
- Liver and biliary diseases and regenerative medicine: “Liver, posterior view. ( )” John Campbell / CC0 (cropped)
- Pancreatic surgery and islet transplantation: “Islet transplantation PLoS Medicine” Giovanni Maki / CC BY 2.5 (cropped)
- Research to improve liver transplantation: “Gray1086-liver” Henry Vandyke Carter / Public domain (cropped)
- Developing surgical devices through medical-engineering collaboration: “US Navy 060426-N-5174T-068 Hospital Corpsman 1st Class Cynthia Donaldson prepares surgical tools before an inguinal hernia repair in the operating room” U.S. Navy photo by Journalist 2nd Class Shane Tuck / Public domain (cropped)
- Related lab (Thoracic Surgery Lab): “Lung transplant” National Heart Lung and Blood Institute (NIH) / Public domain (cropped)
- Related lab (Gastrointestinal Surgery Lab): “Da Vinci Surgery” Gashriram / CC BY-SA 4.0 (cropped)
- Related lab (Neurosurgery Lab): “MRA Moya-moya-disease” commons:User:MBq, commons:User:SBarnes / CC BY-SA 3.0 (cropped)
- Related lab (Oral Surgery Lab): “Dental Implant Key Terms” 95Berlin / CC BY-SA 2.5 (cropped)
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