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Advanced Biomedical Engineering Lab
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The lab creates marker molecules for detecting disease early.
AboutAbout the lab
Creating molecules that visualize the inside of the body
The Advanced Biomedical Engineering Lab (Kondo Lab) designs and synthesizes molecular probes that combine the ability to accumulate at specific disease sites such as cancer with the ability to generate the signals needed for imaging, in order to enable early detection of disease and improve diagnostic accuracy.
The lab carries out the full research sequence, through to evaluating function and efficacy in cell and animal experiments, and also works on organometallic chemistry centered on ruthenium complex catalysts.
Key terms
- Molecular probe
- A marker molecule that accumulates at a specific place in the body and makes it visible in images
- Contrast agent
- A drug used in imaging such as MRI to make the area of interest show up clearly
- Photoacoustic
- A method that creates images from the ultrasound waves emitted by tissue exposed to light. Also called PA imaging
ResearchResearch themes
Built on four pillars—molecular probes, molecular imaging, functional molecular chemistry, and organometallic chemistry—the lab creates multifunctional molecular probes for advanced in vivo imaging.
*Illustrative imageHighly sensitive MRI contrast agents
The lab designed ligands incorporating dendrimers, which are regularly branched synthetic polymers, and synthesized new Gd-based MRI contrast agents. They showed relaxivity an order of magnitude higher than that of contrast agents used in clinical practice.
*Illustrative imageImaging with both photoacoustics and MRI
The lab is developing probes that enable photoacoustic imaging and MRI at the same time. It has succeeded in synthesizing Gd2O3 nanoparticles surface-modified with gelatin, and is also working on MnO and CoO nanoparticles.
*Illustrative imageDelivering probes to the intended site
Compounds that enter the body are quickly excreted. The lab applies drug delivery systems equipped with mechanisms that sense environments such as tumors to molecular probes, in order to improve accumulation efficiency and retention in the blood.
*Illustrative imageRuthenium complex catalysts
Using a zero-valent ruthenium complex catalyst developed in the lab, the researchers discovered a reaction in which three alkenes link together with high selectivity. The lab has also developed alcohol oxidation using air as the oxidant and an efficient method for constructing indole rings.
MembersFaculty
- ProfessorTeruyuki Kondo
- Associate ProfessorYu Kimura
- Assistant ProfessorRisako Miura
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “PET MRI Scanner (NIH BioArt )” Courtesy of NIAID Malcolm Houston / Public domain (cropped)
- Highly sensitive MRI contrast agents: “Gadoteric acid” Edgar181 / Public domain (cropped)
- Imaging with both photoacoustics and MRI: “Gadolinium-2” Jurii / CC BY 3.0 (cropped)
- Delivering probes to the intended site: “Redox-Responsive Drug Delivery” BioRender.com / CC0 (cropped)
- Ruthenium complex catalysts: “Colors of ruthenium(III) complexes” Leiem / CC BY-SA 4.0 (cropped)
- Related lab (基礎炭化水素化学): “Confocal micrograph of stained HeLa” Dedyseptiadi7 / CC BY-SA 4.0 (cropped)
- Related lab (生物有機化学): “Crystal Jelly ("Aequorea Victoria"), Monterey Bay Aquarium, Monterey, California, USA” Jim G from Silicon Valley, CA, USA / CC BY 2.0 (cropped)
- Related lab (高分子機能物性): “Natural latex collected” Vis M / CC BY-SA 4.0 (cropped)
- Related lab (分子集合体化学): “CSIRO ScienceImage 11637 Scanning electron microscope image of the seed inside the MOF crystals” Dr Paolo Falcaro and Dr Dario Buso, CSIRO / CC BY 3.0 (cropped)
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