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Avian Bioscience Lab
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A lab studying genetic modification and germ cells in chickens and quail.
AboutAbout the lab
Building a sustainable society with familiar birds.
The Avian Bioscience Lab uses chickens and quail to study how genes govern biological phenomena in birds.
Using methods from cell engineering, developmental engineering, and molecular biology, the lab works on projects such as generating genetically modified avian model animals.
The lab also studies how primordial germ cells, which will become sperm and eggs, differentiate and proliferate.
Using mutant strains maintained by the Avian Bioscience Research Center, the lab also identifies the genes responsible for mutant traits and elucidates their functions.
Key terms
- Primordial germ cells
- Germ cells at the embryonic stage; stem cells that will differentiate into sperm or eggs.
- Genome editing
- A technology for rewriting targeted parts of an organism's genome (its entire genetic information).
- Sugar chain (glycan)
- Sugars linked together in a chain. They are built by enzymes acting in sequence and are involved in the activity of hormones and antibodies.
ResearchResearch themes
Using familiar birds such as chickens and quail, the lab works to elucidate avian biological phenomena while developing technologies such as genetic modification and genome editing. It handles everything from enzymes, E. coli, viruses, and cells to whole animals, combining methods such as genetic engineering and animal cell culture.
*Illustrative imageProduction of Genetically Modified and Genome-Edited Birds
The lab aims to make genetic modification and genome editing in birds more efficient and to put them to use. It is producing chickens that express a fluorescent protein throughout the body and chickens that produce a hormone for pharmaceuticals inside their eggs.
*Illustrative imageAnalysis of Avian Primordial Germ Cells
The lab focuses on primordial germ cells, the germ cells at the embryonic stage. In chickens they can be maintained in long-term pure culture, but this is not possible in quail, which belongs to the same family (Phasianidae). The lab studies the mechanisms of their proliferation and differentiation.
*Illustrative imageProducing Useful Proteins and Vaccines in Eggs
The structure of sugar chains is involved in the activity of hormones and antibodies and in the propagation of vaccines. Controlling these sugar chains is expected to further improve the production of useful substances using chickens.
*Illustrative imageAnalysis and Use of Useful Traits in Birds
Birds generally have high blood glucose, and the lab has found a strain with an especially high level. It aims to clarify how these birds avoid developing diabetes despite such high levels.
MembersFaculty
The members of the Avian Bioscience Lab consist of faculty, students in the doctoral program, master's program, and undergraduate program, and administrative staff.As of 2022
- ProfessorKenichi Nishijima
- Assistant ProfessorYuya Okuzaki
- Assistant ProfessorLiang Ren
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “Egg incubator” Vyperx1 / Public domain (cropped)
- Production of Genetically Modified and Genome-Edited Birds: “Coturnix coturnix eggs” Mnolf / CC BY-SA 3.0 (cropped)
- Analysis of Avian Primordial Germ Cells: “Sterile 24-Well Cell Culture Plate Used in Laboratory Research” Gannu03 / CC BY-SA 4.0 (cropped)
- Producing Useful Proteins and Vaccines in Eggs: “Chicken Egg without Eggshell 5859” Biswarup Ganguly / CC BY 3.0 (cropped)
- Analysis and Use of Useful Traits in Birds: “Coturnix coturnix, Somerset East District, Eastern Cape, South Africa 1” baldcoot / CC0 (cropped)
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- Related lab (Developmental Biology and Systems Plant Science Lab): “Pimelea simplex” Kym Nicolson / CC BY 4.0 (cropped)
- Related lab (Integrative Animal Physiology Lab): “Coturnix japonica, Yehliu, Taiwan 1” 孫鋒 林 from Taipei, Taiwan / CC BY-SA 2.0 (cropped)
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