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Respiratory Medicine Lab
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A lab that explores intractable respiratory diseases from both basic and clinical perspectives.
AboutAbout the lab
Exploring the mechanisms and treatment of intractable lung diseases.
The lab conducts research, clinical care, and education on a wide range of respiratory diseases, including lung cancer, interstitial pneumonia, and respiratory infections.
Many intractable lung diseases have mechanisms that are still unknown. To elucidate disease pathophysiology and develop new treatments, the lab hopes to promote advanced basic research as well as translational research that only clinicians can do.
Taking advantage of its strong network of affiliated hospitals, the lab also says it wants to advance multicenter collaborative studies that generate new evidence.
Clinical care is provided as the Department of Respiratory Medicine of Nagoya University Hospital.
Key terms
- Translational research
- Bridging research that connects the results of basic research to the clinical care of patients.
- Direct reprogramming
- A technology that directly induces lung epithelial cells from fibroblasts and other cells.
- Biomarker
- A tool for predicting the course of a disease.
NewsLab news
A medical student won the "Resident and Student Award"
A doctoral student won second place at the 43rd Internal Medicine Pathophysiology Department Internal Research Presentation Meeting
Prof. Ishii's research on generating lung epithelial cells through direct reprogramming was published in npj Regenerative Medicine
ResearchResearch themes
The lab aims to elucidate the pathophysiology of intractable respiratory diseases and develop new treatments, working on advanced basic research and translational research that only clinicians can do. Its research spans a wide range, from lung regeneration to thoracic tumors and infectious diseases, and is carried out in collaboration with basic research departments.
*Illustrative imageLung Regeneration through Direct Reprogramming
For intractable lung diseases in which damaged lungs are extremely unlikely to recover on their own, the lab is working to develop a new regenerative medicine approach using direct reprogramming, a technology that directly induces lung epithelial cells from fibroblasts and other cells.
*Illustrative imagePathological Analysis of Interstitial Lung Disease
For interstitial lung diseases, including pulmonary fibrosis, most of the disease mechanisms remain unknown. Through analysis of samples obtained in clinical care and experiments using animals and cells, the lab is working to develop new treatment strategies and biomarkers.
*Illustrative imageDiagnosis and Treatment of Thoracic Malignancies
Besides lung cancer, malignant pleural mesothelioma and thymoma/thymic carcinoma also have an extremely poor prognosis, and research aimed at long-term survival and cure is needed. To answer open questions in diagnosis and treatment, the lab conducts investigator-initiated clinical trials, specified clinical research, translational research, and basic research.
*Illustrative imageMultifaceted Research on Respiratory Infections
The lab pursues research from multiple angles, including clinical research, host immunity research, and microbiology research. Its projects include a multicenter prospective clinical study of pneumonia conducted with affiliated hospitals, analysis of host immune responses that leads to the development of new treatments, and research on microbial diagnosis and infection prevention conducted jointly with other research institutions.
MembersFaculty
The faculty of the Respiratory Medicine Lab consists of a Professor, Associate Professor, Hospital Lecturer, Assistant Professor, and Hospital Assistant Professor.As of 2026
- ProfessorMakoto Ishii
- Associate Professor, Head of Medical DepartmentKoji Sakamoto
- Hospital LecturerIchidai Tanaka
- Assistant ProfessorAkira Ando
- Assistant ProfessorTakayasu Ito
- Assistant ProfessorReiko Matsuzawa
- Hospital Assistant ProfessorKazumi Hori
- Hospital Assistant ProfessorJunji Kamiyama
- Hospital Assistant ProfessorShunsaku Hayai
- Hospital Assistant Professor and Member of the Emergency Medical Care Management HeadquartersYuta Mori
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “Device for Spirometry or Body Plethysmography 02” Joe Mabel / CC BY-SA 3.0 (cropped)
- Lung Regeneration through Direct Reprogramming: “Regenerative medicine” Andrewrgross / CC BY-SA 4.0 (cropped)
- Pathological Analysis of Interstitial Lung Disease: “Wrist-oximeter” UusiAjaja / CC0 (cropped)
- Diagnosis and Treatment of Thoracic Malignancies: “Oncology ward” Lovelyn Obiakor / CC BY-SA 4.0 (cropped)
- Multifaceted Research on Respiratory Infections: “Bacteria on agar plate” HansN. / CC BY-SA 3.0 (cropped)
- Related lab (Vascular Surgery (Surgery I) Lab): “Drug-eluting stent” https://www.scientificanimations.com/ / CC BY-SA 4.0 (cropped)
- Related lab (Neurology Lab): “Reflex hummer2” Tachypnoe / CC BY-SA 4.0 (cropped)
- Related lab (Oral and Maxillofacial Surgery Lab): “Beneath the surface- unfiltered moments of oral surgery (8036058)” U.S. Air Force photo by Staff Sgt. Jacob Wongwai / Public domain (cropped)
- Related lab (Human Augmentation and Hand Surgery Lab): “Surgical instruments used in gynecology” GiftedLydia / CC BY-SA 4.0 (cropped)
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