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Time-Controlling Molecules Lab
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A lab that explores the mechanisms of the body's rhythms using compounds that modulate the circadian clock.
AboutAbout the lab
Searching for compounds that modulate the circadian clock
The Time-Controlling Molecules Lab studies the circadian clock, which governs daily rhythms in many bodily functions, such as sleep-wake cycles and metabolism.
It is known that disruption of the circadian clock, through shift work or genetic mutations, can lead to diseases such as sleep disorders, metabolic diseases, and cancer.
Combining biochemistry and chemical biology, the lab uses original compounds to study how the circadian clock works at the molecular level.
The lab is located at the Institute of Transformative Bio-Molecules (ITbM) and is introduced on the website as the "Kay-Hirota Group."
Key terms
- Circadian clock
- The internal timekeeping mechanism of the body that governs daily rhythms such as sleep-wake cycles and metabolism
- Chemical biology
- A research approach that uses chemical compounds to investigate how living organisms work
- CRY
- Clock proteins that make up the circadian clock. There are two types, CRY1 and CRY2
ResearchResearch themes
The lab studies, at the molecular level, the circadian clock that governs daily rhythms in many bodily functions, such as sleep-wake cycles and metabolism. It finds compounds that act on the clock and clarifies how they work, and it also carries out basic research toward treating diseases linked to circadian clock disruption.
*Illustrative imageDiscovery of compounds that modulate the circadian clock
From a large number of compounds, the lab has found several that change the circadian rhythms of human cells. It has identified compounds that act selectively on each of the clock proteins CRY1 and CRY2, and has also clarified how this selectivity arises from the structures of the compound-protein complexes.
*Illustrative imageBasic research toward treating diseases
The lab has found that compounds acting on CRY suppress gluconeogenesis in liver cells and promote the differentiation of brown adipocytes. It has also found that compounds that inhibit the kinase CK2 suppress the proliferation of acute myeloid leukemia cells.
MembersFaculty
Members of the Time-Controlling Molecules Lab consist of faculty, postdoctoral researchers, PhD students, undergraduate students, technicians, technical assistants, and administrative assistants.
- Project Associate ProfessorTsuyoshi Hirota
- Project Associate ProfessorMegumi Hatori
VoicesStudent voices
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “Toluene-3D-molecular-model-engraved-render-CAS-108-88-3” MolGod Scientific / CC BY-SA 4.0 (cropped)
- Discovery of compounds that modulate the circadian clock: “Protein Imager molecular rendering example 3 CsgFG complex” Molpgraphfan / CC BY-SA 4.0 (cropped)
- Basic research toward treating diseases: “Multiwell cell culture plate-zoom” Lilly_M / CC BY-SA 3.0 (cropped)
- Related lab (Plant Chemical Genetics Lab): “Striga hermonthica single flower” Aneth David (SLU) / CC BY-SA 4.0 (cropped)
- Related lab (Endocrine Signaling Lab): “Drosophila melanogaster under a microscope 01” Gannu03 / CC BY-SA 4.0 (cropped)
- Related lab (Cellular Drug Efficacy Analysis Lab): “Virtual reality headset” FloppaIngénieur / CC BY 4.0 (cropped)
- Related lab (Multicellular Order Lab): “Plant Tissue Culture Lab - Atlanta Botanical Garden” Daderot / CC BY-SA 4.0 (cropped)
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