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Endocrine Signaling Lab
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The lab studies how hormones regulate the internal environment and growth.
AboutAbout the lab
Linking the internal environment and development through hormones.
The Endocrine Signaling Lab studies how the internal environment and growth are regulated by the action of hormones.
The lab focuses on the endocrine system, which regulates homeostasis of the internal environment.
It investigates the mechanisms that regulate homeostasis of ions such as calcium, as well as those that regulate growth, metamorphosis, innate behavior, and reproduction.
The lab aims to elucidate the basic principles by which animals keep their internal environment stable, and the principles by which environmental information regulates development and physiological states.
Key terms
- Endocrine system
- Endocrine system: a mechanism in which distant organs communicate with each other using hormones to regulate the state of the body
- Homeostasis
- Homeostasis: keeping the internal environment of the body in a stable state
- Peptide hormone
- Peptide hormone: a hormone made of amino acids linked together
- Metamorphosis
- Metamorphosis: a major change in body form from larva to adult
NewsLab news
Paper: A paper by Professor Okamoto and colleagues was published in iScience
Paper: A paper by Professor Okamoto and colleagues was published in Nature
ResearchResearch themes
The lab studies how the hormone-based endocrine system maintains the internal environment and regulates growth and development. By uncovering hormone networks that link multiple organs, it aims to elucidate their basic principles.
*Illustrative imageHormones that maintain calcium in the body
Building on a peptide hormone that regulates calcium concentration in body fluids and on calcium storage organs, the lab investigates unknown hormones that act when calcium is in excess, as well as mechanisms that maintain homeostasis of other ions.
*Illustrative imageHormones that regulate growth and metamorphosis
The lab carries on a tradition of research on hormones that control growth, molting, metamorphosis, and diapause in insects. Beyond growth and metamorphosis, it extends its scope to innate behavior and reproduction, aiming to elucidate the principles by which environmental information regulates development and physiological states through the endocrine system.
MembersFaculty
- ProfessorNaoki Okamoto
VoicesStudent voices
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “Drosophila melanogaster under a microscope 01” Gannu03 / CC BY-SA 4.0 (cropped)
- Hormones that maintain calcium in the body: “Calcium oxalate crystals in Urine Microscopy” Ajay Kumar Chaurasiya / CC BY-SA 4.0 (cropped)
- Hormones that regulate growth and metamorphosis: “Monarch butterfly with its pupa case” Avenue / CC BY-SA 3.0 (cropped)
- Related lab (Genetics Lab): “Culture vials of Drosophila melanogaster in Unifei” Mateus S. Figueiredo / CC BY 4.0 (cropped)
- Related lab (Plant Molecular Signaling Lab): “Leaf epidermis” Louisa Howard (Dartmouth electron microscope facility) / Public domain (cropped)
- Related lab (Multicellular Order Lab): “Plant Tissue Culture Lab - Atlanta Botanical Garden” Daderot / CC BY-SA 4.0 (cropped)
- Related lab (Neural Circuit Structure Lab): “Minettia fly” Ermell / CC BY-SA 4.0 (cropped)
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