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Biological Mechanisms Lab
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The lab studies nerve regeneration and degeneration through the lens of signaling.
AboutAbout the lab
Approaching nerve regeneration and degeneration through signal transduction.
The Biological Mechanisms Lab studies the molecular mechanisms that regulate neuronal axon regeneration, neurodegenerative diseases, and neural function, as well as their signaling networks.
Living organisms change their functions and morphology in response to external stimuli and other cues, and thereby regulate biological phenomena such as development, regeneration, and behavior.
In its research, the lab performs molecular biological analyses using nematodes, fish, and mice.
Key terms
- Nematode
- Nematode (C. elegans): an animal 1 to 2 mm long that lives in soil and feeds on microorganisms. It is a model animal that is easy to analyze genetically
- Signal transduction
- Signal transduction: the mechanism by which stimuli received by an organism are linked to an appropriate biological response
- α-Synuclein
- α-Synuclein: a protein that aggregates and spreads in the brain in Parkinson's disease, 10 to 20 years before symptoms appear
NewsLab news
Paper: A paper by a PhD student was published in PNAS
Paper: A paper on the regulation of axon regeneration by RNA modification was published in PLoS Genetics
Paper: A paper by a PhD student and Lecturer Nakano was published in PNAS
Paper: A paper by Assistant Professor Ito was published in Development
Lecturer Shunji Nakano joins the lab
ResearchResearch themes
In the cells and bodies of living organisms, signals received from inside and outside are coordinated to regulate biological phenomena such as development, regeneration, and behavior. This lab uses nematodes, fish, and mice to study the molecular mechanisms that regulate neuronal axon regeneration, neurodegenerative diseases, and neural function, along with their signaling networks.
*Illustrative imageSignal transduction regulating neuronal axon regeneration
Using nematodes, the lab seeks to understand in an integrated way, from the gene level to the whole-organism level, the role of signal transduction that regulates the regeneration of severed nerves. It aims to build a new foundation that will lead to research on treatments for nerve injury.
*Illustrative imageα-Synuclein aggregation and synaptic degeneration
In the prodromal stage of the disease, α-synuclein aggregates and spreads in the brain, and the function of neuronal synapses is gradually impaired. Using primary cultured neurons and glial cells from mice, the lab studies these mechanisms at the molecular and cellular levels.
MembersFaculty
The members of the Biological Mechanisms Lab consist of faculty, PhD, master's, and undergraduate students, technical staff, and a secretary.As of 2026
- ProfessorNaoki Hisamoto
- Associate ProfessorHiroshi Hanafusa
- LecturerShunji Nakano
- Assistant ProfessorTsubasa Ito
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “Petri Dish with HEK293 (NIH BioArt 653)” Courtesy of NIAID Ryan Kissinger / Public domain (cropped)
- Signal transduction regulating neuronal axon regeneration: “AxonTurning” Chris1387 (talk) / CC BY-SA 3.0 (cropped)
- α-Synuclein aggregation and synaptic degeneration: “Synapse figure” Curtis Neveu / CC BY-SA 4.0 (cropped)
- Related lab (Cell Regulation Lab): “Molecular Cell Biology Laboratory - LUMC” mararie from Leiden, The Netherlands / CC BY-SA 2.0 (cropped)
- Related lab (Organ Function Lab): “Biology lab Cedar Point Biological Station” Scott L. Gardner / CC BY-SA 4.0 (cropped)
- Related lab (Microbial Motility Lab): “Microbiology techniques 1” Luis Fernando Flores LAB / CC BY-SA 4.0 (cropped)
- Related lab (Plant Pattern Formation Lab): “Arabidopsis thaliana seedling” Alena Kravchenko / CC BY-SA 4.0 (cropped)
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