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Cell Regulation Lab
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A lab that focuses on septins and explores the pathology of psychiatric and neurological disorders in mice.
AboutAbout the lab
Exploring the pathology of psychiatric and neurological disorders through genetically modified mice
The lab focuses on proteins such as septins, which are highly expressed in the brain and nervous system, and uses genetically modified mice to study the mechanisms of human psychiatric and neurological diseases.
Septins are cytoskeletal proteins, alongside actin and tubulin, that regulate cell shape and rigidity.
Using abnormalities in behavior such as cognitive function, motor function, and sociality as clues, the lab searches for molecular mechanisms that remain unknown.
Key terms
- Septin
- A protein that polymerizes from filaments to rings. Along with actin and tubulin, it is one of the cytoskeletal systems.
- Genetically modified mice
- Mice created by modifying a specific gene. Those with specific abnormalities can serve as models of human diseases.
- Hippocampal dentate gyrus
- A region of the hippocampus in the brain. This region has been established as the one responsible for the memory impairment of Sept3-deficient mice.
ResearchResearch themes
Actin, tubulin, and septins regulate cell shape and rigidity and, by generating force in cooperation with motor proteins, are responsible for cell division, movement, material transport, differentiation, and more. The lab focuses on septins and adapter molecules that are highly expressed in the brain and nervous system, creates genetically modified mice, and explores unknown molecular mechanisms from behavioral abnormalities.
*Illustrative imageGenes and environment in cognitive function
The lab studies the function of the septin gene SEPT3, located in a genomic region associated with human cognitive function. The memory impairment of Sept3-deficient mice originates in the hippocampal dentate gyrus and improved in a housing environment that increased physical activity. The lab is investigating the mechanism behind this.
*Illustrative imageReproducing causative genes of intellectual disability in mice
The lab introduces numerous genetic mutations found in pediatric patients with intellectual disability, epilepsy, and other conditions into the brains of mouse fetuses and neonates, and examines their effects. By efficiently screening the effects of the mutations, it aims to clarify the mechanisms of the pathology.
MembersFaculty
- ProfessorMakoto Kinoshita
- Assistant ProfessorMasashi Nishikawa
- Assistant ProfessorChikako Nakajima
VoicesStudent voices
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “Molecular Cell Biology Laboratory - LUMC” mararie from Leiden, The Netherlands / CC BY-SA 2.0 (cropped)
- Genes and environment in cognitive function: “Cytoskeleton-2021” Illustration by David S. Goodsell, RCSB Protein Data Bank. doi: 10.2210/rcsb_pdb/goodsell-gallery-036 / CC BY 4.0 (cropped)
- Reproducing causative genes of intellectual disability in mice: “Нейрон коры с множеством дендритных шипиков” Sergb95 / CC BY-SA 4.0 (cropped)
- Related lab (Molecular Expression and Regulation Lab): “Tabletop centrifuge” Magnus Manske / CC BY 1.0 (cropped)
- Related lab (Biological Mechanisms Lab): “Petri Dish with HEK293 (NIH BioArt 653)” Courtesy of NIAID Ryan Kissinger / Public domain (cropped)
- Related lab (Cell Structure Lab): “Physcomitrella Sporophyt” Manuel Mildner & Annette Hohe / CC BY-SA 4.0 (cropped)
- Related lab (Cell Spatiotemporal Control Lab): “Elodea cells under microscope” ~delta / CC BY-SA 4.0 (cropped)
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