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Biomolecular Applied Chemistry Lab
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A lab that draws on both chemistry and biology to create molecules useful for research and drug development.
AboutAbout the lab
Seeing what could not be seen, creating what could not be made
The Murakami Lab draws on knowledge from both chemistry and biology to create molecules useful for biological research and drug development.
It also combines the molecules it makes to build new methods in analytical chemistry.
Its current focus is creating artificial antibodies that bind to chosen targets, using TRAP display, a method developed in the lab.
No specialized knowledge of chemistry or biology is required; the lab advances its research by discussing ideas together.
Key terms
- Artificial antibody
- A protein smaller than an antibody that is designed by people to bind to a specific target, as an antibody does
- mRNA
- A molecule that copies genetic information and serves as the blueprint when proteins are made
- D-form
- The mirror-image form of the L-form amino acids normally found in the body
NewsLab news
A master's student won a Poster Award at the 2nd Domain Meeting of Transformative Research Areas (A)
A master's student won a Poster Award at the 20th Annual Meeting of the Japanese Society for Chemical Biology
A paper on an improved version of cDNA TRAP display was published in ChemBioChem
In joint research with Nagoya Institute of Technology, a paper on creating small-molecule and protein pairs whose binding can be switched by light was published in Nature Chemistry
A doctoral student won a Student Presentation Award at the 106th Annual Spring Meeting of the Chemical Society of Japan
ResearchResearch themes
The lab aims to create molecules useful for biological research and drug development, drawing on knowledge from both chemistry and biology. Currently, it is working on creating artificial antibodies that bind to a variety of targets, using TRAP display, a method developed in the lab.
*Illustrative imageCreating artificial antibodies with TRAP display
From a large pool of artificial antibody candidates in which amino acids have been randomly substituted, the lab selects those that bind to a target. It developed TRAP display, which makes this selection simpler and faster.
*Illustrative imagecDNA TRAP display, which resists degradation
mRNA, the blueprint of an artificial antibody, has the weakness of being easily degraded by enzymes found in everyday environments. The lab improved TRAP display into cDNA TRAP display, which allows stable selection under a variety of conditions.
*Illustrative imageMirror-image artificial antibodies
Artificial antibodies made of D-form amino acids, the mirror image of the L-form, have the advantage of being less readily recognized in the body. By combining TRAP display with chemical protein synthesis, the lab created D-form artificial antibodies that bind to targets in the body.
MembersFaculty
The Murakami Lab consists of faculty members and doctoral, master's, and undergraduate students.As of 2026
- ProfessorHiroshi Murakami
- Associate ProfessorGosuke Hayashi
- Assistant ProfessorMasahito Inagaki
VoicesStudent voices
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “Coronavirus. SARS-CoV-2” Alexey Solodovnikov (Idea, Producer, CG, Editor), Valeria Arkhipova (Scientific Сonsultant) / CC BY-SA 4.0 (cropped)
- Creating artificial antibodies with TRAP display: “Phage display” Thomas Shafee / CC BY 4.0 (cropped)
- cDNA TRAP display, which resists degradation: “Disposable Pipette Tips in Laboratory Tip Boxes” Gannu03 / CC BY-SA 4.0 (cropped)
- Mirror-image artificial antibodies: “Salbutamol-S-enantiomer-3D-balls” Ben Mills / Public domain (cropped)
- Related lab (Emergent Measurement Chemistry Lab): “A group of scientists working in a laboratory Esculab” Esculab / CC0 (cropped)
- Related lab (Chemical Genetics Lab): “Pipetten” No machine-readable author provided. Newbie~commonswiki assumed (based on copyright claims). / Public domain (cropped)
- Related lab (Biosupramolecular Chemistry Lab): “Dna-163466” PublicDomainPictures / CC0 (cropped)
- Related lab (Cellular and Molecular Informatics Lab): “Biotechnology lab” Timothydotuns / CC BY-SA 4.0 (cropped)
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