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Yura Lab
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The lab uses computers to read biological data and solve the mysteries of living things.
AboutAbout the lab
Using computation to solve mysteries hidden in the data of life.
The Yura Lab studies computational methods for analyzing biomolecular data measured with cutting-edge technologies, as well as their applications.
Its targets include predicting the structure and function of proteins encoded in genomes, and estimating the mechanisms by which genetic variants lead to disease.
When existing methods cannot solve a problem, the lab develops new methods of its own.
The lab draws on all of its knowledge of science and engineering, including biology, physics, and information science.
Key terms
- Bioinformatics
- A field that uses computers to analyze large amounts of data obtained from living organisms
- Homology modeling
- A method for predicting the three-dimensional structure of an unknown protein based on the structure of a known protein with a very similar sequence
- Splicing
- The process of cutting out unneeded parts from RNA transcribed from a gene and joining the remaining parts together
NewsLab news
A paper reporting the results of an international collaboration was published
A master's student received the Junior Investigator Poster Award at NEURO2026
A paper from a collaborative study on the mechanism that determines diapause in cricket eggs was published
A paper co-authored with lab alumni and others was published in BBRC
A doctoral student received the Student Excellent Presentation Award at the annual meeting of the Japanese Society for Marine Biotechnology
ResearchResearch themes
The Yura Lab carries out its research using the lab's computing resources. Its themes follow two axes: one starts from biological questions and solves them with existing methods, and the other starts from technical problems and improves or newly develops bioinformatics methods.
*Illustrative imageSolving biological questions
These themes start from biological questions and use existing methods to solve them. Topics include post-transcriptional RNA modification in eukaryotes, the mechanism of splicing and the origin of introns, the selection of exons that undergo alternative splicing, RNA editing, the DNA damage repair mechanisms of radiation-resistant bacteria, and the mechanisms that allow bacteria to withstand high temperatures.
*Illustrative imageBuilding bioinformatics methods
These themes start from technical problems and substantially improve bioinformatics methods or develop new ones. The lab is developing a high-accuracy homology modeling method and a database of model structures, methods for predicting the sites where proteins bind to RNA, DNA, other proteins, and small molecules, prediction of RNA higher-order structure, and methods for inferring function from structure.
MembersFaculty
- ProfessorKei Yura
VoicesStudent voices
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “Myoglobin” AzaToth / Public domain (cropped)
- Solving biological questions: “DNA Helix CPK” Ude / Public domain (cropped)
- Building bioinformatics methods: “Tertiary structure C10orf53” https://zhanggroup.org/I-TASSER/ / CC BY-SA 4.0 (cropped)
- Related lab (Takeda Lab): “3D printed Hydrogel Scaffold” Habannn / CC0 (cropped)
- Related lab (Hosokawa Lab): “Single cell sequencing （MDA） (cropped)” Qianli Ma / Public domain (cropped)
- Related lab (Asahi Lab): “Ibuprofen-crystals-polarized-light-microscopy” Janeklass / CC BY 4.0 (cropped)
- Related lab (Takeyama Lab): “Petri dish 2” Drhx / CC BY-SA 4.0 (cropped)
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