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Matsuda Lab
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A neurobiology lab that studies synaptic plasticity underlying memory and learning and seeks ways to control it.
AboutAbout the lab
Decoding the synaptic changes that underlie memory and learning.
The Matsuda Lab aims to elucidate the molecular mechanisms of synaptic plasticity, which underlies memory and learning, and to develop methods to control it.
Synapses are the sites where neurons exchange information, and how efficiently signals are transmitted changes depending on stimulation.
It has been shown that this change is, in essence, a change in the number of AMPA-type glutamate receptors at the synapse.
The lab investigates how TARP, a protein that binds to these receptors, and proteins that bind to TARP affect plasticity, while also working to develop methods for controlling synaptic plasticity with light.
Key terms
- Synaptic plasticity
- The phenomenon in which how efficiently signals are transmitted at a synapse changes with stimulation. It is thought to be the cellular basis of memory and learning.
- AMPA-type glutamate receptor
- A receptor that mainly mediates excitatory synaptic transmission in the central nervous system. Its channel opens when glutamate binds to it.
- TARP
- A protein that binds tightly to AMPA-type glutamate receptors. It is involved in regulating the intracellular trafficking of the receptors.
- Endocytosis
- The process by which a cell takes in material from its surface into its interior.
ResearchResearch themes
Neurons exchange information with each other at sites called synapses. This lab aims to elucidate the molecular mechanisms of synaptic plasticity, in which the efficiency of information transmission at synapses changes, and to develop methods to control it. The information on the lab website dates from around 2016.
*Illustrative imageThe role of TARP in inducing synaptic plasticity
The lab has shown that TARP, which binds to AMPA-type glutamate receptors, binds to transport-regulating molecules such as AP-2 and AP-3 depending on its phosphorylation state, thereby controlling the intracellular trafficking of the receptors and inducing synaptic plasticity. The lab is now analyzing how various proteins that bind to TARP affect the induction of plasticity.
*Illustrative imageControlling synaptic plasticity with light
Long-term depression, one form of synaptic plasticity, occurs when AMPA-type glutamate receptors on the cell surface are taken up by endocytosis, reducing the number of receptors. The lab is developing a method to control this endocytosis with light, and plans to extend it to technologies for controlling memory and learning at the level of the whole organism.
MembersFaculty
The members of the Matsuda Lab are faculty, UEC postdoctoral researchers, industry-academia-government collaboration researchers, and master's and undergraduate students.
- Associate ProfessorShinji Matsuda
VoicesStudent voices
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “Layer V Pyramidal cell from mouse visual cortex” Quorumetrix / CC BY-SA 4.0 (cropped)
- The role of TARP in inducing synaptic plasticity: “Molecular view of glutamatergic synapse” Maria Voigt and PDB-101 / CC BY 4.0 (cropped)
- Controlling synaptic plasticity with light: “Figure-1” https://kids.frontiersin.org/article/10.3389/frym. / CC BY 2.5 (cropped)
- Related lab (Shirakawa Lab): “Calcium fluorescence imaging schematic” PeaBrainC / CC BY-SA 4.0 (cropped)
- Related lab (Kano Lab): “Microscope stage set up for intravital microscopy” Aleanora / CC BY-SA 4.0 (cropped)
- Related lab (Kuboki-Kajikawa Lab): “Kopenhagen (DK), Nyhavn” Dietmar Rabich / CC BY-SA 4.0 (cropped)
- Related lab (Ueno Lab): “Propagation of light through the core of an optical fiber. Macro visualization.” AZToshkov / CC BY-SA 3.0 (cropped)
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