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Yamada Lab
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The lab reads the origins and reaction histories of organic molecules from stable isotopes.
AboutAbout the lab
Revealing the origins and reaction histories of organic molecules.
The Yamada Lab studies how to read the origin and reaction history of organic molecules from small variations in their stable isotope composition.
The ratios of stable isotopes of hydrogen, carbon, nitrogen, oxygen, and other elements that make up organic molecules change slightly when the molecules undergo physical changes or chemical reactions.
The lab develops methods to precisely measure and analyze these variations, and applies them to organic molecules in the atmosphere and oceans, in foods and beverages, and in living organisms and cells.
Supervision of undergraduate thesis students and graduate students is carried out jointly with the Toyoda Lab in the same Department of Chemical Science and Engineering.
Key terms
- Stable isotope
- Atoms of the same element that differ in mass. They do not decay over time, and their ratios change only slightly.
- Volatile organic compound
- An organic molecule that evaporates easily into the air at room temperature. It affects air quality and human health.
- Biomarker
- A substance in the body that gives clues about a person's condition or whether they have a disease.
NewsLab news
View More ↗ResearchResearch themes
The stable isotope composition of hydrogen, carbon, nitrogen, oxygen, and other elements that make up organic molecules varies slightly through physical changes and chemical reactions. The lab develops methods to precisely measure and analyze these variations, and uses them to reveal the origins and reaction histories of organic molecules found in the atmosphere, food, living organisms, and other settings.
*Illustrative imageMeasuring organic molecules in the atmosphere
Highly reactive organic molecules in the atmosphere strongly affect the atmospheric environment through atmospheric chemical reactions, even in very small amounts. The lab has identified the sources of methane from its hydrogen and carbon stable isotope composition, and also investigates the sources and reaction processes of volatile organic compounds.
*Illustrative imageIdentifying the origin of foods and beverages
From the viewpoint of food safety and quality assurance, the lab develops chemical methods to determine whether organic molecules in foods and beverages are natural or synthetic, and where they come from.
*Illustrative imageUnderstanding changes in the body through metabolism
Blood, urine, and breath contain volatile organic compounds as metabolites, which are expected to serve as biomarkers reflecting disease and physiological conditions. By sensitively detecting metabolic abnormalities from variations in their stable isotope composition, the lab aims to develop new methods of disease diagnosis.
*Illustrative imageDeveloping methods to measure isotopes
The lab develops methods to extract and measure very small amounts of target molecules from complex mixtures, as well as methods to separate the elements that make up a molecule one by one and measure the isotope composition of each. These make it possible to read more detailed information about origins and reaction histories.
MembersFaculty
The members of the Yamada Lab are faculty, graduate students in doctoral and master's programs, and undergraduate students.As of 2026
- Associate ProfessorKeita YamadaPublications ↗
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “Gas Chromatograph Autosampler” Hey Paul from Sacramento, CA, USA / CC BY 2.0 (cropped)
- Measuring organic molecules in the atmosphere: “Noctilucent (mesospheric) clouds” Igor da Bari / CC BY 4.0 (cropped)
- Identifying the origin of foods and beverages: “Snipping the bunch ( )” Rexness / CC BY-SA 2.0 (cropped)
- Understanding changes in the body through metabolism: “Isotope ratio ms” 作者不詳 / Public domain (cropped)
- Developing methods to measure isotopes: “EA-IRMS, isotope ratio mass spectrometer with elemental analyzer for the determination of isotope ratios of stable isotopes in wines, spirits, honey and natural sweeteners, in CAFIA laboratory” Sarka Na kopci / CC BY-SA 4.0 (cropped)
- Related lab (Toyoda Lab): “Sunset from the ISS” ISS Expedition 23 crew / Public domain (cropped)
- Related lab (Fukushima-Shoji Lab): “Emerging geometry in life building blocks” FedeCaimi / CC BY 4.0 (cropped)
- Related lab (Ito Lab): “Diamond by Peter Smyth” Peter Smyth / CC0 (cropped)
- Related lab (Nakazono Lab): “B-cyclodextrin” Materialscientist / CC BY-SA 4.0 (cropped)
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