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Ishida Lab
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The lab uses micromachine technology to build fingertip-sized bio laboratories.
AboutAbout the lab
Building a bio laboratory on a fingertip
The Ishida Lab studies a new interdisciplinary field by applying mechanical engineering technology to medicine and biology, and knowledge from medicine and biology to mechanical engineering.
Using MEMS and microchannel technology, the lab develops new measurement devices for examining living organisms and biological materials.
By combining these technologies, the lab creates fingertip-sized bio laboratories and is opening up technology that supports biomedical research and drug discovery.
Key terms
- MEMS
- Technology that uses semiconductor fabrication processes to build tiny mechanical parts and sensors on a substrate
- Microchannel
- A groove as thin as a hair carved into a chip, through which very small amounts of liquid or cells can be flowed and handled
- Directed evolution
- A method of repeating mutation and selection to give an organism a desired trait
NewsLab news
Exhibited the lab's work at Suzukake Science Day
A student won the Miura Award from the Japan Society of Mechanical Engineers
A student won the Excellent Presentation Award at a workshop of the Society for Chemistry and Micro-Nano Systems
A student won a Poster Award at the international conference ISBE2025
A master's student won the Outstanding Presentation Award of the Life Engineering Course
ResearchResearch themes
Based on MEMS and microchannel technology, the lab develops new measurement devices for living organisms and biological materials. It also makes devices that draw out the capabilities of living organisms and biological materials for applications in engineering and medicine.
*Illustrative imageMEMS for Nanoscale Observation in Liquid
The lab develops MEMS liquid cells, in which a thin membrane separates a liquid from a vacuum, and uses them to observe bacteria and viruses in liquid in fine detail with an electron microscope. It also examines the interfaces where gels rub against each other.
*Illustrative imageChips for Evolving and Fusing Bacteria
The lab develops microchannels that accelerate directed evolution by repeatedly subjecting droplets containing bacteria to mutation, selection, and growth. It also works on technology that fuses bacteria with each other at low voltage.
*Illustrative imageIntegrating Cancer Tissue and Intestine into Channels
The lab develops a method in which cancer tissue extracted with a biopsy needle is placed in a microchannel and examined by flowing culture medium through it. It also studies how to visualize the flow near the villi, treating a section of small intestine as a channel.
*Illustrative imageShrinking Ice Crystals in Narrow Channels
To freeze and preserve cells without damaging them, the lab studies ways to suppress ice crystal formation without using cryoprotectants. Freezing inside a microchannel suppressed the formation of ice crystals.
MembersFaculty
The members of the Ishida Lab consist of faculty, doctoral, master's, and undergraduate students, administrative staff, and technical support staff.As of 2026
- Associate ProfessorTadashi IshidaPublications ↗
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “Microfluidic chip for point-of-care medical devices” FMNLab / CC BY 4.0 (cropped)
- MEMS for Nanoscale Observation in Liquid: “E coli at 10000x, original” Photo by Eric Erbe, digital colorization by Christopher Pooley, both of USDA, ARS, EMU. / Public domain (cropped)
- Chips for Evolving and Fusing Bacteria: “Microfluidic Reservoir” Kimbalm / CC BY-SA 4.0 (cropped)
- Integrating Cancer Tissue and Intestine into Channels: “Cross-section histology of small intestinal villi of the terminal ileum” Mikael Häggström, M.D. / CC0 (cropped)
- Shrinking Ice Crystals in Narrow Channels: “Snowflake macro photography 1” Alexey Kljatov / CC BY-SA 4.0 (cropped)
- Related lab (Takayama Lab): “Worm drive ( )” Bernard Spragg. NZ from Christchurch, New Zealand / CC0 (cropped)
- Related lab (Shinshi Lab): “Science show magnetic levitation” Roberto Arias from London, United Kingdom / CC BY 2.0 (cropped)
- Related lab (Tadano Lab): “Instruments for laparoscopic Hernia Operation” Anpol42 / CC BY-SA 3.0 (cropped)
- Related lab (Nisisako Lab): “T Junction Microfluidic Device” Wongbria / CC BY-SA 4.0 (cropped)
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