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Developmental Genetics Lab (Ishikawa Lab)
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The lab uses fruit flies (Drosophila) to explore the genetic programs that shape animal bodies.
AboutAbout the lab
Reading the blueprint of form from genes.
The Developmental Genetics Lab studies how animal bodies are formed.
The form of a multicellular organism is built and maintained according to a genetic program unique to that organism.
The lab believes that even seemingly complex phenomena can be understood as combinations of events at the level of cells and molecules.
Focusing on cell-to-cell communication, the lab combines in vitro biochemistry with genetics using Drosophila melanogaster.
Key terms
- Golgi apparatus
- An organelle that attaches sugars and tags to proteins within the cell and sorts them to their destinations.
- Phosphorylation
- A chemical modification in which a phosphate group is attached to a protein. It acts as a switch that changes the protein's activity.
- Planar cell polarity
- The property by which cells within a sheet align their orientation in the same direction. It is involved in the shaping of tissues.
ResearchResearch themes
In multicellular organisms, interactions between cells play an important role in building the body and maintaining its state. The lab seeks to understand the mechanisms and functions of this cell-to-cell signaling by combining in vitro biochemistry with Drosophila melanogaster, an organism amenable to genetic approaches.
*Illustrative imageA Golgi Kinase and Tissue Formation
The plasma membrane proteins Fat and Dachsous, which govern tissue growth and planar cell polarity, are phosphorylated in their extracellular regions by the Golgi kinase Four-jointed. Because phosphorylation outside the cell has also proven important for regulating their function, the lab is investigating its physiological roles.
*Illustrative imageSearching for Enzymes That Act Outside the Cell
Four-jointed was the first Golgi kinase to be identified at the molecular level. In recent years, enzymes that phosphorylate the extracellular domains of proteins inside the endoplasmic reticulum and Golgi apparatus have been found one after another, and the lab aims to discover new enzymes acting in the secretory pathway and clarify their functions.
MembersFaculty
- Associate ProfessorHiroyuki Ishikawa
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “Fruitfly cultures ( )” Brian Gratwicke from DC, USA / CC BY 2.0 (cropped)
- A Golgi Kinase and Tissue Formation: “Structure of the human STK3 kinase domain” Huza90 / CC BY-SA 4.0 (cropped)
- Searching for Enzymes That Act Outside the Cell: “PDB 1o94 EBI” Jawahar Swaminathan and MSD staff at the European Bioinformatics Institute / Public domain (cropped)
- Related lab (Cell Function Regulation Lab (Matsura-Itakura Lab)): “Gram positive budding yeast cells” Microrao / CC BY-SA 4.0 (cropped)
- Related lab (Animal Evolutionary Ecology Lab): “Hermit crab with a shell on a sandy bottom at night” Dmitry Domrin / CC BY 4.0 (cropped)
- Related lab (Biological Molecular Motor Lab (Ito-Haraguchi Lab)): “Chara coralllina var. kyusyuensis” Show_ryu / CC BY-SA 3.0 (cropped)
- Related lab (Epigenome Structure and Dynamics Lab (Osakabe Lab)): “Arabidopsis Thaliana planted in Laboratory” Jucember / CC BY-SA 3.0 (cropped)
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