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Molecular Drug Discovery Lab (Eisai Co., Ltd. Tsukuba Research Laboratories)
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A partner graduate school lab that investigates how drug candidates behave in the body by measuring them.
AboutAbout the lab
Measuring drug behavior and toxicity to predict them.
The Molecular Drug Discovery Lab is a lab of the University of Tsukuba's partner graduate school program, based at Eisai Co., Ltd.'s Tsukuba Research Laboratories.
The lab develops highly sensitive methods for measuring drug concentrations and biomarkers, which are indicators of the body's condition, for pharmaceuticals and candidate compounds.
Using results from in vitro studies and studies with genetically modified animals, the lab investigates how drugs move through the body and how they are metabolized and excreted. This leads to "PK/PD prediction" of how drugs will behave and work in humans.
The lab aims to establish evaluation systems using cells and other materials to predict drug toxicity and clarify its mechanisms.
Key terms
- Biomarker
- An indicator measured from the body to gauge the state of a disease or how well a drug is working. Substances in the blood are often used.
- PK/PD prediction
- PK refers to changes in drug concentration in the body, and PD refers to how a drug's effects appear. This means estimating both of these in humans.
- In vitro studies
- Studies conducted outside a living organism, such as in test tubes or cultured cells. Studies in animals are called in vivo studies.
ResearchResearch themes
The lab develops highly sensitive methods to measure drug concentrations and biomarkers for candidate compounds, and investigates their behavior in the body through in vitro studies and studies using genetically modified animals. Based on the mechanisms identified, it builds models, makes predictions for humans, and verifies them against clinical trial results.
View More ↗MembersFaculty
- Academic AdvisorYuji Mano
- Co-advisorKazuya Morikawa
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “Gravity liquid chromatography column-01” Lilly_M / CC BY-SA 3.0 (cropped)
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