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Structural Biochemistry Lab
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A lab that explores the causes of disease and drug discovery through the structures of molecules.
AboutAbout the lab
Solving the mysteries of life from molecular structure
The Structural Biochemistry Lab studies the mysteries of life and the causes of disease by determining the structures of molecules.
For structural analysis, the lab uses cryo-electron microscopy with single-particle analysis, as well as X-ray crystallography.
Targeting viruses, bacteria, and soft tissue tumors, the lab performs structural analysis with the aim of contributing to drug discovery.
On the lab's website, it is introduced under the name "Iwasaki Lab."
Key terms
- Cryo-electron microscope
- An electron microscope used to determine the three-dimensional structure of molecules. The lab uses it for structural analysis and also operates the facility
- SBDD
- Designing drugs based on the structure of the molecule that causes a disease (Structure-Based Drug Design)
- Soft tissue tumor
- Tumors that the lab targets for structural analysis. Synovial sarcoma and Ewing sarcoma are given as examples
ResearchResearch themes
The lab aims to clarify the mysteries of life and the causes of disease from the structures of molecules, with structural analysis at the center of its research. Using SBDD (structure-based drug design), which designs drugs from the structures of disease-causing molecules, the lab aims to contribute to drug discovery targeting viruses, bacteria, and soft tissue tumors.
*Illustrative imageStructural analysis of molecules that cause soft tissue tumors
The lab analyzes the structures of molecules that cause soft tissue tumors known as synovial sarcoma and Ewing sarcoma. It aims to contribute to drug discovery targeting soft tissue tumors.
*Illustrative imageOperating a state-of-the-art cryo-electron microscope
As part of a project of AMED (Japan Agency for Medical Research and Development), a state-of-the-art cryo-electron microscope is installed in the lab. Alongside supporting many private companies, the lab works to extend this toward drug discovery.
MembersFaculty
The members of the Structural Biochemistry Lab are faculty members, researchers, research engineers, doctoral, master's, and undergraduate students, and secretaries.As of 2025
- ProfessorKenji Iwasaki
- Associate ProfessorNaruhiko Adachi
- Assistant ProfessorAyaka Harada
- Assistant ProfessorKazashi Kato
- Assistant ProfessorRyo Fujiki
- Assistant ProfessorGen Sabun
VoicesStudent voices
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “Advanced Microscopy Laboratory ( )” Oak Ridge National Laboratory / CC BY 2.0 (cropped)
- Structural analysis of molecules that cause soft tissue tumors: “CSIRO ScienceImage 418 XRay Crystallography Protein Crystals” division, CSIRO / CC BY 3.0 (cropped)
- Operating a state-of-the-art cryo-electron microscope: “Hitachi-7100-transmission-electron-microscope-equipped-with-a-gatan-high-resolution-digital-bottom-mount-camera-3-1024x683” Oak tree road 1 / CC BY-SA 4.0 (cropped)
- Related lab (分析化学): “Lasers; Optics ( )” National Institute of Standards and Technology / Public domain (cropped)
- Related lab (機能物質化学): “Scrutinyite crystal structure (Wyckoff 1963) polyhedra model on (001)” Ra'ike (Wikipedia) / CC0 (cropped)
- Related lab (有機元素化学): “Àtẹ Èròjà Aláìlábùlà (Yoruba Periodic Table of the Elements)” Taofeeq Adebayo / CC BY-SA 4.0 (cropped)
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