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Prof. Mori's Next-Generation Pediatric Medicine / Pediatric Physiology (National Center for Child Health and Development) Lab
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The lab explores the molecular actions unique to children, with an eye toward treating intractable pediatric diseases.
AboutAbout the lab
Exploring the strengths of children at the molecular level
The Mori Lab studies the molecular mechanisms that give rise to properties specific to children (juvenility), with a view to treating intractable pediatric diseases.
The lab is located at the Research Institute of the National Center for Child Health and Development in Setagaya, Tokyo, and as a cooperative graduate school of Tohoku University, it accepts doctoral students.
Using whole-genome analysis, imaging, and a range of molecular biology methods without limiting itself to any one of them, the lab searches for ways to cure diseases.
The lab's website presents it under the name “Masaki Mori Lab.”
Key terms
- Cooperative graduate school
- A system in which graduate students receive research supervision at a research institution outside the university and can earn a degree from that graduate school
- Juvenile genes
- A group of genes that are highly active in childhood and decline in activity in adulthood. They were identified in mice by this lab
- Transcriptome
- The complete set of gene transcripts (RNA) active in a cell
- Whole-genome analysis
- An analysis that reads and examines the entire genetic information (genome) of an organism at once
NewsLab news
Second-round recruitment for the doctoral program in Medical Science at Tohoku University Graduate School has begun
A paper reporting differences inside mitochondria was published in Disease Models & Mechanisms
ResearchResearch themes
Aiming to cure intractable pediatric diseases, the lab studies the molecular mechanisms that give rise to the properties specific to children, known as “juvenility.” Alongside basic research, it also works on diagnosis by whole-genome analysis and on clinical research.
Molecular mechanisms of juvenility
The lab believes that “juvenile genes,” which are highly active only in childhood, bring about cell behaviors specific to childhood and functions such as growth, development, and regeneration, and it investigates these mechanisms. It aims to connect the findings to understanding the causes of intractable diseases and developing treatments.
*Illustrative imageRegenerative medicine using stem cells
The lab is exploring regenerative medicine using iPS cells, ES cells, and tissue stem cells. Focusing on cells that resemble childhood stem cells, it works on understanding the pathology of childhood cancers and developing regenerative medicine technologies.
*Illustrative imageRapid whole-genome diagnosis
Making use of technical advances in genome analysis and informatics, the lab uses rapid whole-genome analysis for diagnosis and for elucidating molecular pathology. Experts in child health and development have come together for this work.
*Illustrative imageNeurodevelopment and maturation of the hypothalamus
The lab clarifies the molecular pathology of neurodevelopment using the latest technologies such as single-cell analysis, spatiotemporal transcriptome analysis, and behavioral analysis. This is neuroscience research.
MembersFaculty
The members of the Mori Lab consist of the department head, staff scientists, secretaries, doctoral and master's students, and undergraduate students.As of 2026
- Visiting ProfessorMasaki Mori
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “Test tubes in a laboratory” Sarka Na kopci / CC BY-SA 4.0 (cropped)
- Regenerative medicine using stem cells: “Petri Dish (NIH BioArt 404)” Courtesy of NIAID Ryan Kissinger / Public domain (cropped)
- Rapid whole-genome diagnosis: “DNBSEQ-G400” RPSkokie / CC BY-SA 4.0 (cropped)
- Neurodevelopment and maturation of the hypothalamus: “GFP Neurons” ManuelSchottdorf / CC BY-SA 4.0 (cropped)
- Related lab (Stem Cell Medicine Lab): “Onion cells under the fluorescence microscope 2” Kateryna Kot / CC BY-SA 4.0 (cropped)
- Related lab (Center for the Promotion of Medical Education): “Group of Medical Student” Mawcsthojai / CC0 (cropped)
- Related lab (Pediatric Development Lab (Tohoku Medical Megabank Organization)): “Séquençage du génome d'une microalgue au laboratoire GENALG (Ifremer )” Stephane Lesbats (IFREMER, Pôle Images, Centre Bretagne - ZI de la Pointe du Diable - CS Plouzané, France) / CC BY 4.0 (cropped)
- Related lab (AI Frontier Medical Innovation Lab (Center for Innovative and Applied Medicine)): “Séquençage du génome d'une microalgue au laboratoire GENALG (Ifremer )” Stephane Lesbats (IFREMER, Pôle Images, Centre Bretagne - ZI de la Pointe du Diable - CS Plouzané, France) / CC BY 4.0 (cropped)
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