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Applied Biomolecular Analysis Lab
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The lab explores how proteins work from their three-dimensional structures.
AboutAbout the lab
Understanding proteins through their structures and applying their properties
The Applied Biomolecular Analysis Lab aims to clarify how various proteins work from their three-dimensional structures, focusing on proteins related to disease.
Using molecular analysis methods such as X-ray crystallography, spectroscopic analysis, and thermodynamic analysis, the lab investigates in detail how each protein functions.
The lab also conducts research aimed at applying the properties it uncovers to the design of new materials with higher-order functions.
Key terms
- X-ray crystallography
- A method of shining X-rays on a protein that has been crystallized to determine how its atoms are arranged
- Hemocyanin
- A giant protein found in the blood of squid, octopus, shellfish, and others that uses copper to carry oxygen
- Drug resistance
- The property by which antibiotics stop working against bacteria
- FtsZ
- A protein that bacteria need when they divide their cells
NewsLab news
Prof. Tanaka received the FY2025 President's Education Award
Prof. Tanaka received the FY2025 Tohoku University Award for Contribution to University-Wide Education
A doctoral student received an Excellence Award in the poster awards at the 4th Annual Meeting of the Japanese Society for Antibody Science
Research results by a doctoral student were published in Cell Reports
A master's student received a Poster Award at the 25th Annual Meeting of the Protein Science Society of Japan
ResearchResearch themes
The lab aims to understand proteins from their structures and to apply their properties. Focusing on disease-related proteins, it investigates their molecular mechanisms using molecular analysis methods such as X-ray crystallography.
*Illustrative imageProteins involved in Staphylococcus aureus disease
Staphylococcus aureus readily acquires drug resistance and is a problematic cause of hospital-acquired infections. To obtain information useful for drug discovery, the lab studies the structures and functions of drug-resistance-related proteins, cell surface proteins, and pore-forming toxin proteins.
*Illustrative imageStructural analysis of the giant protein hemocyanin
The blood of squid and octopus is blue because they carry oxygen with hemocyanin, a giant protein that contains copper. The lab's website introduces research in which the overall structure of hemocyanin from the Japanese flying squid was determined by X-ray crystallography, and the way its many functional domains assemble was examined.
*Illustrative imageStructures of antibacterial molecules and their target proteins
The lab's website introduces research that examined, from three-dimensional structures, the structural changes of FtsZ, a protein required for bacterial cell division, and how a compound that inhibits it works. The lab is also analyzing the reactions of enzymes that make antibacterial compounds and developing artificial enzymes that can produce new antibacterial molecules.
MembersFaculty
The members of the Applied Biomolecular Analysis Lab consist of faculty, research assistants, and doctoral, master's, and undergraduate students.As of 2026
- ProfessorYoshikazu Tanaka
- Assistant ProfessorNoha Elshamy
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “LOV2 domain of phototropin-2 protein from Arabidopsis thaliana” TBwichem / CC0 (cropped)
- Proteins involved in Staphylococcus aureus disease: “Staphylococcus aureus bacteria escape” =(Credit: NIAID/RML) / Public domain (cropped)
- Structural analysis of the giant protein hemocyanin: “Squid komodo” Nhobgood / CC BY-SA 3.0 (cropped)
- Structures of antibacterial molecules and their target proteins: “Antimicrobial susceptibility testing (AST) result of Leuconostoc” Ajay Kumar Chaurasiya / CC0 (cropped)
- Related lab (Enzyme Chemistry Lab): “Crystal Structure of Human WAPL (PDB 4K6J)” Jimcricket90 / CC BY-SA 4.0 (cropped)
- Related lab (Molecular Biochemistry Lab): “Chromatin (NIH BioArt )” Courtesy of NIAID Ryan Kissinger / Public domain (cropped)
- Related lab (Applied Microbiology Lab): “Microbiology techniques 2” Luis Fernando Flores LAB / CC BY-SA 4.0 (cropped)
- Related lab (Eukaryotic Microbial Functions Lab): “Koji Mold Rice” Zenyrgarden / CC BY-SA 4.0 (cropped)
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