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Stem Cell Biology Lab
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The lab explores disease mechanisms and therapeutic targets by studying aging and cancerous transformation of brain stem cells.
AboutAbout the lab
Finding disease mechanisms and therapeutic targets in stem cell abnormalities.
The lab studies how neural stem cells in the brain, and the progenitor cells one step before mature cell types, proliferate and differentiate into other cell types.
It investigates how stem cells and progenitor cells change with age, how fates such as aging and cancerous transformation are determined, and how this leads to disease.
Based on this knowledge, the lab aims to develop new therapies.
The lab belongs to the Institute for Genetic Medicine and corresponds to the Stem Cell Biology Laboratory in the Department of Cancer Pathology at the Graduate School of Medicine.
Key terms
- Neural stem cell
- Neural stem cell: a cell in the brain that can self-renew while also differentiating into neurons, glial cells, and other cell types.
- Oligodendrocyte
- Oligodendrocyte: a glial cell in the brain and spinal cord that wraps neuronal axons and helps nerve signals travel faster.
- Cancer stem cell
- Cancer stem cell: a cell within a tumor that self-renews and gives rise to various cancer cells. It is thought to be a cause of recurrence.
NewsLab news
Discovery that the cell-surface molecule Eva1 is involved in visceral fat dysfunction associated with obesity
Joint research with RIKEN succeeds in producing an antibody-drug conjugate effective against glioblastoma stem cells
ResearchResearch themes
Using neural stem cells and oligodendrocyte progenitor cells, the lab investigates the mechanisms of self-renewal and of differentiation into other cell types. It studies how age-related changes in stem cells and progenitor cells lead to aging, cancerous transformation, and the onset of disease, with the aim of creating new therapies.
*Illustrative imageMechanisms of differentiation into oligodendrocytes
The lab investigates how progenitor cells differentiate into oligodendrocytes. Through a comprehensive screen using RNA interference, it identified the factor Odire, which regulates both morphological changes and the activity of genes involved in differentiation.
*Illustrative imageBrain tumor stem cells and new therapies
The lab examined the properties of glioma stem cells generated from neural stem cells and progenitor cells, and identified a membrane protein specific to cancer stem cells. In collaboration with RIKEN, it is producing an antibody that targets this membrane protein, with the goal of developing a therapy.
*Illustrative imageCellular senescence and age-related diseases
The lab established an experimental system for cellular senescence using progenitor cells and identified Ecrg4, a secreted factor involved in aging. It is investigating the receptor and signaling mechanisms of Ecrg4 and its relationship to cancer and age-related neurological diseases.
MembersFaculty
The members of the Stem Cell Biology Lab are faculty, postdoctoral researchers, and research support staff.As of 2022
- ProfessorToru Kondo
- LecturerYolee Son
- Assistant ProfessorNaoto Oikawa
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “"Forest of memory"” RebecaCuesta / CC BY-SA 4.0 (cropped)
- Mechanisms of differentiation into oligodendrocytes: “Oligodendrocytes” Oleg Tsupykov / CC BY-SA 4.0 (cropped)
- Brain tumor stem cells and new therapies: “Immagine di cellula di Glioblastoma multiforme della mia linea cellulare patentata presso ECACC ANGMCSS” Notarangelo Angelantonio / CC BY 4.0 (cropped)
- Cellular senescence and age-related diseases: “Cellular senescence” Velichko Artem / CC BY 4.0 (cropped)
- Related lab (Medical Safety Management Lab): “Banská Bystrica - FNsP FDR - interiér -005” Ladislav Luppa / CC0 (cropped)
- Related lab (Molecular Neuroimmunology Lab): “Fluorescently Labeled Microglia in a Coronal Brain Section from a C57 Mouse” Syed07 / CC BY 4.0 (cropped)
- Related lab (Obstetrics and Gynecology Lab): “Placenta (265 26) Section of human placenta” Doc. RNDr. Josef Reischig, CSc. / CC BY-SA 3.0 (cropped)
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