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Bioorganic Chemistry Lab
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A lab that explores the compounds made by marine microbes through genes and organic chemistry.
AboutAbout the lab
Solving the mysteries of compounds made by marine organisms
The Bioorganic Chemistry Lab studies compounds made by marine organisms and microbes from the perspective of organic chemistry.
A wide variety of compounds, some of which are candidates for drugs, have been found in marine organisms, and many of them are made by symbiotic bacteria.
The lab aims to find the genes needed to make these compounds and produce them biotechnologically, making use of marine resources that have not yet been utilized.
The lab also investigates how organisms influence one another through chemical substances, in connection with red tides and cyanobacterial blooms (aoko).
Key terms
- Metagenomics
- A method of extracting DNA directly from seawater, seafloor mud, and other samples, without culturing the microbes, and analyzing it
- Algicidal bacteria
- Bacteria that can kill the algae that cause red tides and cyanobacterial blooms
- Red tides and cyanobacterial blooms (aoko)
- Phenomena in which phytoplankton multiply excessively in seas or lakes and change the color of the water. They cause damage to fisheries and the environment
ResearchResearch themes
From the perspective of organic chemistry, the lab studies compounds made by marine organisms and microbes, the genes that produce them, and their roles in interactions between organisms. It also uses metagenomics, which analyzes DNA from environmental samples in bulk, and bioinformatics.
*Illustrative imageSearching marine metagenomes for useful genes
Using metagenomics, which extracts DNA directly from microbes that cannot be cultured, the lab searches for genes for producing useful substances. It is also developing methods to actually produce the compounds using the genes it finds.
*Illustrative imageControlling red tides and cyanobacterial blooms with algicidal bacteria
The lab aims to develop environmentally friendly measures against red tides and cyanobacterial blooms by using bacteria that kill harmful algae. By combining the identification of algicidal substances, genome analysis of the bacteria, and analysis of environmental water, it investigates how algal killing occurs in nature.
MembersFaculty
- Associate ProfessorMasaki Fujita
- Assistant ProfessorHiromi Watari
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “Aplysina archeri (Stove-pipe Sponge-pink variation)” Nhobgood (talk) Nick Hobgood / CC BY-SA 3.0 (cropped)
- Searching marine metagenomes for useful genes: “Colonie batteriche o vita marina?” Chiara.marraccini / CC BY-SA 4.0 (cropped)
- Controlling red tides and cyanobacterial blooms with algicidal bacteria: “Microcystis aeruginosa outbreak on the southwest side of Lake Albert 1” Bidgee / CC BY-SA 3.0 au (cropped)
- Related lab (食品衛生学
（水産食品科学講座） ): “CSIRO ScienceImage 3619 Examining an agar dish for bacterial colonies as part of the bioremediation project” David McClenaghan, CSIRO / CC BY 3.0 (cropped) - Related lab (生物分析化学
（生物資源化学講座） ): “Fish lined up at a fresh fish store at Tezukayama, Osaka, Japan, February” Laitche / CC BY-SA 4.0 (cropped) - Related lab (機能性分子化学研究室
（生物資源化学講座） ): “Omega 3 Fish oil softgel capsules” Gpkp / CC BY-SA 4.0 (cropped) - Related lab (食品工学
（水産資源開発工学講座） ): “Palmeria palmata” Cwmhiraeth / CC BY-SA 3.0 (cropped)
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