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Animal Molecular Medicine Lab
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The lab works on parasitic diseases, genetic diseases, and blood diseases in dogs.
AboutAbout the lab
Contributing to veterinary medicine through clinical care and lab research
The Animal Molecular Medicine Lab studies parasitic diseases, genetic diseases, and blood diseases in dogs and cats.
Through both clinical care at the affiliated Animal Medical Center and research in the lab, the lab aims to contribute to veterinary medicine.
The lab works on how protozoa that infect canine red blood cells become resistant to drugs, diseases caused by congenital genetic abnormalities, and the treatment of diseases in which the immune system destroys blood cells.
Key terms
- Drug resistance
- When a pathogen becomes resistant to a drug, so that a drug that previously worked no longer works
- Methemoglobinemia
- A condition in which hemoglobin in a form that cannot carry oxygen increases in the blood, making it harder for oxygen to reach the body
- Immunosuppressant
- A drug that suppresses immune function. It is used to treat diseases in which the immune system attacks the body itself
NewsLab news
A paper by Prof. Yamasaki and colleagues was published in Journal of Veterinary Internal Medicine
A paper by Prof. Yamasaki and colleagues was published in Veterinary Radiology & Ultrasound
ResearchResearch themes
Focusing on diseases of dogs, the lab investigates at the gene and molecular level how pathogens become resistant to drugs and what causes diseases resulting from genetic abnormalities. For diseases in which the immune system destroys blood cells, it also conducts clinical research to improve treatment outcomes.
*Illustrative imageCanine Babesia Becoming Resistant to Drugs
Babesia gibsoni, a protozoan that infects canine red blood cells, acquires resistance to treatment drugs and becomes hard to cure. By comparing drug-sensitive and drug-resistant strains using methods such as next-generation sequencing, the lab clarifies the mechanism and aims to lead to the development of new treatments.
*Illustrative imageCongenital Methemoglobinemia in Dogs
The lab analyzes a genetic disease caused by congenitally weak activity of the enzyme that converts methemoglobin back to hemoglobin. It has been confirmed in Pomeranians and Toy Poodles, and the cause is a single-nucleotide mutation in a gene.
*Illustrative imageTreating Diseases in Which the Immune System Destroys Blood Cells
In severe anemia of unknown cause (PIMA), the lab has shown that dogs that have had the spleen removed survive longer, and it continues to work on clarifying the pathology. For immune thrombocytopenia (ITP), in which platelets are destroyed, the lab is trying to confirm the effect of immunosuppressants other than steroids in a randomized controlled trial.
MembersFaculty
The members of the Animal Molecular Medicine Lab are faculty, doctoral and undergraduate students, and research students.As of 2025
- ProfessorMasahiro Yamasaki
- Associate ProfessorKeitaro Morishita
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “Toy Poodle wearing clothes in Tokyo” Basile Morin / CC BY-SA 4.0 (cropped)
- Canine Babesia Becoming Resistant to Drugs: “Blood smear of Babesia microti, original” Mikael Häggström, M.D. Author info - Reusing images- Conflicts of interest: None Mikael Häggström, M.D.Consent note: Consent from the patient or patient's relatives is regarded as redundant, because of absence of identifiable features (List of HIPAA identifiers) in the media and case information (See also HIPAA case reports guidance). / CC0 (cropped)
- Congenital Methemoglobinemia in Dogs: “Pomeranian profile” Горбунова М.С. / CC BY-SA 4.0 (cropped)
- Treating Diseases in Which the Immune System Destroys Blood Cells: “Red blood cells (2)” Scootdive (talk · contribs) / CC BY-SA 3.0 (cropped)
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（附 属動物病院） ): “Camp Lemonnier Service members Perform Surgery on Hektor, a Djiboutian K-9 Working Dog DVIDS217501” Master Sgt. Carlotta Holley / Public domain (cropped) - Related lab (薬理学教室): “Human astrocyte” Bruno Pascal / CC BY-SA 3.0 (cropped)
- Related lab (微生物学教室): “Swan kussyaro” 鳴神響一
（Kyoichi Narukami） / CC BY 3.0 (cropped)
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