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Photonic Information and Life Science Lab
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The lab combines optical and information technologies to create new tools for life science.
AboutAbout the lab
Pioneering the fusion of light, information, and life
The Photonic Information and Life Science Lab (Mikami Lab) makes full use of optical and information technologies to create life science tools that overturn conventional wisdom.
Alongside opening up new science, the lab aims to give its research back to society by putting the technologies it develops to practical use.
With its strength in understanding light thoroughly and controlling it freely, the lab develops measurement technologies that extract the information needed from living systems, as well as data processing and analysis technologies, and actively incorporates AI.
The lab actively collaborates not only within the lab but also with external collaborators.
Key terms
- Fluorescence microscope
- A microscope that labels targets with dyes or proteins that glow when illuminated, so that specific objects inside cells and tissues can be seen by their glow.
- Multiphoton excitation
- A method of making molecules fluoresce by having them absorb two or more photons at the same time. Only a very narrow region at the focal point glows, and the light reaches deep into living tissue.
- Deep learning
- An AI technique in which a neural network with many stacked layers learns features from large amounts of data.
NewsLab news
A preprint on a high-speed light-sheet microscope was released
A master's student received the Poster Award at the RIES-HOKUDAI International Symposium
A master's student received the OPJ Excellent Presentation Award at Optics & Photonics Japan 2024
Paper published in Nature Communications, with a press release
A fourth-year undergraduate student received the Hokkaido University School of Engineering Dean's Award
ResearchResearch themes
The ultimate goal of the lab is to create cutting-edge optical and information technologies and bring revolutionary progress to life science. It also aims to give its research back to society by putting results to practical use and commercializing them.
*Illustrative imageUltrafast 3D fluorescence microscopy
The lab has developed 3D fluorescence microscopy technology that can image three-dimensional samples at up to 1,000 volumes per second, and continues to improve its performance. It is expected to be applied to observing fast-moving biological samples, membrane potential imaging, and more, and the lab is advancing these applications through collaborative research.
*Illustrative imageUltrafast multiphoton imaging and optical manipulation
Multiphoton excitation reaches deep inside living tissue and makes it possible to illuminate only selected cells in 3D space. The lab develops ultrafast multiphoton imaging and optical manipulation technologies that bring out these properties to the fullest.
*Illustrative imageSpeeding up fluorescence microscopy with deep learning
Making fluorescence microscopy imaging faster lowers resolution and sensitivity. The lab develops technology that uses deep learning to compensate for this, enabling fast imaging while maintaining image quality. It also builds its own networks tailored to each purpose.
MembersFaculty
The members of the Photonic Information and Life Science Lab consist of faculty, experimental assistants, administrative assistants, and doctoral, master's, and undergraduate students.As of 2026
- ProfessorHideharu Mikami
- Assistant ProfessorAyumu Ishijima
- Project Assistant ProfessorYusuke Tomina
VoicesStudent voices
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “FluorescentCells” 作者不詳 / Public domain (cropped)
- Ultrafast 3D fluorescence microscopy: “Principle of Light Sheet Fluorescence Microscopy (LSFM)” ZEISS Microscopy / CC BY 2.0 (cropped)
- Ultrafast multiphoton imaging and optical manipulation: “Diagram of a two-photon excitation microscope en” user:Akira.pl / CC BY-SA 3.0 (cropped)
- Speeding up fluorescence microscopy with deep learning: “Colored neural network” Glosser.ca / CC BY-SA 3.0 (cropped)
- Related lab (Integrated Nanosystems Lab): “Нейрон коры с множеством дендритных шипиков” Sergb95 / CC BY-SA 4.0 (cropped)
- Related lab (Integrated Architecture Lab): “A semiconductor wafer being removed from processing equipment” YouTube — Purdue Engineering / CC BY 4.0 (cropped)
- Related lab (Information Analysis Lab): “Dilution Fridge with Quantum Processors Enclosed 008 8K” OJB Quantum / CC BY 4.0 (cropped)
- Related lab (Information Knowledge Network Lab): “Code on computer monitor (Unsplash)” Markus Spiske markusspiske / CC0 (cropped)
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