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Yamada Lab
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The lab uses iPS cell reprogramming technology to study the mechanisms of cancer and aging.
AboutAbout the lab
Molecular pathology at the whole-organism level, through reprogramming technology
The Department of Molecular Pathology uses the technology for generating iPS cells (reprogramming) to study the mechanisms of cancer and aging.
Epigenetic regulation, the mechanism that controls gene activity without changing the DNA sequence, is important for cell differentiation, and it is increasingly understood to be involved in carcinogenesis and aging as well.
The lab has created "Reprogrammable mice," in which cell fate can be altered inside the living animal, and is carrying out analyses using them.
Based on these findings, the lab aims to develop new treatments for disease, as well as methods for organ regeneration and rejuvenation.
Key terms
- iPS cells
- Cells made by introducing genes into somatic cells such as skin cells, which can then turn into many different types of cells
- Reprogramming
- Returning differentiated cells to a state in which they can turn into many different types of cells. Also called cellular reprogramming or cell initialization
- Epigenetic regulation
- Mechanisms such as DNA methylation that switch gene activity on and off without changing the base sequence
ResearchResearch themes
Using mouse developmental engineering and reprogramming technology that can control the epigenome, the lab creates mice in which cell fate can be changed in vivo. It aims to understand epigenetic regulation in a wide range of biological phenomena, such as cell differentiation and the maintenance of homeostasis in the body.
*Illustrative imageCancer research using reprogramming technology
The lab applies reprogramming technology to cancer cells to alter their epigenetic state, searching for the true abnormalities involved in carcinogenesis. It investigates the relationship between dedifferentiation of cancer cells and carcinogenesis, and is also developing technology to screen for anticancer drugs that focus on changing the fate of cancer cells.
*Illustrative imageTissue regeneration and rejuvenation inside the body
Using Reprogrammable mice, in which iPS cells can be induced inside the body, the lab analyzes the process by which cell fate changes in vivo. By clarifying the mechanisms of aging and tissue regeneration, it aims to develop methods for tissue regeneration and rejuvenation.
*Illustrative imageExpanding pancreatic islet cells toward a cure for diabetes
The lab studies how to expand mature pancreatic islet cells using reprogramming technology based on the Mycl gene. It aims to apply this to islet transplantation and gene therapy, and to develop technology that restores the function of aged islets.
MembersFaculty
The members of the Department of Molecular Pathology consist of faculty members, researchers, collaborators and visiting researchers, a lab manager, graduate students, undergraduate students, and secretaries.As of 2023
- ProfessorYasuhiro Yamada
- Associate ProfessorYosuke Yamada
- Assistant ProfessorSho Ota
- Assistant ProfessorNao Mikoda
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “Иммуноцитохимическое окрашивание культуры клеток человека” Daria Goliusova / CC BY 4.0 (cropped)
- Cancer research using reprogramming technology: “DNA methylation notext” Mariuswalter / CC BY-SA 4.0 (cropped)
- Tissue regeneration and rejuvenation inside the body: “Lab mouse mg 3140” Rama / CC BY-SA 2.0 fr (cropped)
- Expanding pancreatic islet cells toward a cure for diabetes: “Encapsulated Islet of Langerhans ( )” Berkshire Community College Bioscience Image Library / CC0 (cropped)
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（水島昇研究室） ): “Multicolor fluorescence image of living HeLa cells” 8x57is / CC BY-SA 4.0 (cropped) - Related lab (神経生化学教室
（尾藤晴彦研究室） ): “Hippocampal neurons in culture” Guarnieri Fabrizia / CC BY-SA 4.0 (cropped)
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