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Neurochemistry Lab (Bito Lab)
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The lab explores how the brain works by studying the chemical signals that occur at synapses.
AboutAbout the lab
Exploring the "hardwired" and "flexible" sides of neural circuits
The lab studies synapses, which connect neurons to one another, and the transmission of information inside neurons.
Neural circuits have two properties: they are built according to a defined blueprint, and they also change and learn in response to experience.
The ability to change with experience arises from the combination of electrical and chemical signals at synapses.
The lab aims to identify each of these elementary processes and thereby clarify how the brain works.
Key terms
- Synapse
- The junction between neurons, where information is passed on using neurotransmitters and other molecules
- Elementary process
- Each of the basic reactions or steps obtained when a complex event is broken down into its parts
- Actin cytoskeleton
- A framework made of fibers of the protein actin that supports the shape and movement of a cell
ResearchResearch themes
The lab aims to understand the operating principles of the brain by identifying, one by one, the elementary processes of chemical signal transduction that occur inside cells in response to neural activity, and by clarifying how they behave. The lab is developing new analytical methods that examine a single synapse as the unit of study, and is conducting functional analyses of the identified elementary processes in living animals.
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MembersFaculty
The lab's members consist of faculty, postdocs (research fellows), research staff (specialized technical staff), PhD and master's students, and lab staff.As of 2024
- ProfessorHaruhiko BitoPublications ↗
- LecturerHajime Fujii
- Assistant ProfessorKeisuke Ota
- Assistant ProfessorHayato Kondo
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “Hippocampal neurons in culture” Guarnieri Fabrizia / CC BY-SA 4.0 (cropped)
- How neural activity remodels the actin cytoskeleton: “Dendritic spines” http://en.wikipedia.org/w/index.php?title=User:Tmhoogland&action=edit / Public domain (cropped)
- Related lab (Okabe Lab): “Neuron in tissue culture” GerryShaw / CC BY-SA 3.0 (cropped)
- Related lab (Department of Microbiology (Takeda Lab)): “Human Respiratory Syncytial Virus (RSV)” NIAID / CC BY 2.0 (cropped)
- Related lab (Mizushima Lab): “Multicolor fluorescence image of living HeLa cells” 8x57is / CC BY-SA 4.0 (cropped)
- Related lab (Tanaka Lab): “Microtubules in Primary Mouse Embryonic Fibroblasts” Howard Vindin / CC BY 4.0 (cropped)
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