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Kanoh Lab
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The lab works to elucidate the functions of telomeres and subtelomeres at the ends of chromosomes.
AboutAbout the lab
Unraveling the mechanisms of life from the ends of chromosomes
The Kanoh Lab studies the functions of telomeres, located at the ends of chromosomes, and of the subtelomeres adjacent to them.
At the molecular level, the lab aims to clarify how these regions are involved in sustaining life, preserving species, genome evolution, cellular senescence, and the onset of disease.
Using fission yeast, human cells, and cells from great apes, the lab mainly relies on molecular biology, molecular genetics, and cell biology.
To these, it adds next-generation sequencing analysis and structural analysis through collaborative research, investigating the questions from multiple angles.
Key terms
- Telomere
- A structure at the end of the linear chromosomes of eukaryotes, made up of DNA with a special repeated sequence and proteins.
- Subtelomere
- The chromosomal region adjacent to the telomere, with a complex structure in which long common sequences are combined in a mosaic pattern.
- Chromatin
- A folded structure within chromosomes, formed when DNA and proteins bind together.
NewsLab news
Paper on the regulation of telomere function accepted by Genes to Cells
Collaborative paper on chromatin regulation at subtelomeres published on bioRxiv
Paper on the mechanism of formation of condensed structures at subtelomeres accepted by iScience
ResearchResearch themes
The lab studies the functions of telomeres at the ends of chromosomes and of the subtelomeres adjacent to them. Using fission yeast, human cells, and cells from great apes, it applies methods such as molecular biology, molecular genetics, biochemistry, cell biology, and structural biology to explore how these regions are involved in sustaining life, diversification, evolution, and the onset of human disease.
*Illustrative imageTelomeres and the functions of chromosomes
Telomeres are regions required for protecting chromosome ends, elongating telomeric DNA, and carrying out normal meiosis. The lab examines the functions of telomere-binding proteins and has shown, in particular, that the Rap1 protein binds to a variety of other proteins and serves as the central hub of telomere function.
*Illustrative imageElucidating the functions of subtelomeres
The lab is investigating, ahead of the rest of the world, how the special chromatin structure formed at subtelomeres is built and what it does. It has also succeeded in creating cells in which all of the common sequences have been removed from the genome, and has shown that subtelomeres play important roles in maintaining the genome and gene expression.
MembersFaculty
The members of the Kanoh Lab consist of faculty, graduate students, academic specialist staff, and research students.As of 2026
- ProfessorJunko KanohPublications ↗
- Assistant ProfessorTadao Yamamoto
- Project Assistant ProfessorNobuyuki Tanimura
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “HumanChromosomesChromomycinA3” Steffen Dietzel / CC BY-SA 3.0 (cropped)
- Telomeres and the functions of chromosomes: “Telomere quadruplex” user:TimVickers / Public domain (cropped)
- Elucidating the functions of subtelomeres: “Telomeres transparent” AJC1 / CC BY-SA 4.0 (cropped)
- Related lab (佐藤(健)研究室
（高次生体膜機能） ): “Saccharomyces cerevisiae SEM” Mogana Das Murtey and Patchamuthu Ramasamy / CC BY 3.0 (cropped) - Related lab (矢島研究室): “Tetrahymena pyriformis - 400x - Ciliatur ( )” Picturepest / CC BY 2.0 (cropped)
- Related lab (佐藤(守俊)研究室): “Green fluorescent protein (GFP) in Eppendorf Tubes” Juan Carlos Fonseca Mata / CC BY-SA 4.0 (cropped)
- Related lab (若杉(桂輔)研究室): “Angiogenesis medical animation still” www.scientificanimations.com / CC BY-SA 4.0 (cropped)
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