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Ikeuchi Lab
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A lab that recreates outside the body the processes by which neurons and the brain take shape, in order to investigate how they form.
AboutAbout the lab
How do cells build a brain?
The Ikeuchi Lab recreates outside the body the processes by which tissues such as the brain form, and studies how the brain develops as well as related diseases.
The lab investigates how neurons and the brain each build their own characteristic shapes.
The lab aims to generate neural tissue (organoids) from human iPS cells, connect the pieces together, and make them function as neural circuits.
The lab's members are diverse, and the lab has a strongly international character.
Key terms
- iPS cells
- Cells made by modifying the body's cells so that they can grow into many different types of cells
- Organoid
- A small mass of cells that resembles an organ or tissue, made by growing stem cells and similar cells in three dimensions
- Axon
- A long projection extending from a neuron. It acts like a wire, transmitting signals to other neurons
NewsLab news
A paper by Assistant Professor Duenki et al. was published in Communications Biology
A paper by Assistant Professor Duenki et al. was published in Journal of the Japan Society for Precision Engineering
A paper by Professor Ikeuchi et al. was published in Advanced healthcare materials
A paper by Professor Ikeuchi et al. was published in Nature Communications
A paper by Professor Ikeuchi et al. was published in Frontiers in Bioengineering and Biotechnology
ResearchResearch themes
The lab investigates the mechanisms that create the characteristic shapes of neurons and the brain. By clarifying how neurons and the brain are shaped, it aims to elucidate how the brain develops and to overcome brain diseases.
*Illustrative imageShaping of neurons
During development, neurons finely regulate protein synthesis to build their complex shapes. The lab investigates the role of this regulation using biochemical and genetic engineering approaches, aiming to contribute to treatments for brain diseases such as autism and epilepsy.
*Illustrative imageShaping of the brain
The brain is made up of many regions with different functions. The lab builds brain-like tissues using engineering approaches and stimulates each location with chemicals to investigate how the brain becomes divided into distinct regions.
*Illustrative imageNeural circuits connecting brain organoids
The lab has developed technology to connect neural tissues made from human iPS cells through bundles of axons, in a state closer to that inside the body. By building circuits and tissues that mimic part of the brain's functions and activity, the lab aims to elucidate how the brain works.
MembersFaculty
The members of the Ikeuchi Lab consist of faculty, JSPS International Research Fellows, doctoral and master's students, specialist staff and assistants, research fellows, collaborative researchers, research staff, and project researchers.As of 2026
- ProfessorYoshiho IkeuchiPublications ↗
- Assistant ProfessorTomoya DuenkiPublications ↗
- Project Assistant ProfessorAnja Konietzny
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “Human Cerebral Organoids ( )” NIAID / CC BY 2.0 (cropped)
- Shaping of neurons: “Cultured Rat Hippocampal Neuron ( )” ZEISS Microscopy from Germany / CC BY 2.0 (cropped)
- Shaping of the brain: “Human Brain Organoid” Nreis1 / CC BY 4.0 (cropped)
- Neural circuits connecting brain organoids: “Organoid during development ( )” NIH Image Gallery from Bethesda, Maryland, USA / Public domain (cropped)
- Related lab (Neuronal Cell Biology Lab (Hirabayashi Lab)): “Нейрон коры с множеством дендритных шипиков” Sergb95 / CC BY-SA 4.0 (cropped)
- Related lab (Okamoto Lab): “DNA methylation H o” Qubeat / CC BY-SA 4.0 (cropped)
- Related lab (Tsumoto Lab): “Antibody IgG2” TimVickers at English Wikipedia / Public domain (cropped)
- Related lab (Nishimasu Lab): “Acidaminococcus sp. Cas12a PDB 5B43” Deposition authors: Yamano, T., Nishimasu, H., Hirano, H., Nakane, T., Ishitani, R., Nureki, O.; Visualization author: Synpath / CC0 (cropped)
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