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Sando Lab
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The lab uncovers the design principles of biomolecules and takes on the challenge of creating next-generation drugs.
AboutAbout the lab
Uncovering the design principles of molecular function to tackle next-generation drug discovery
The Sando Lab produces a wide variety of biomolecules on a large scale, examines them all at once, and studies how a molecule's shape relates to its role in living organisms.
It clarifies the "design principles" that determine abilities such as passing through cell membranes and distinguishing diseases, and connects them to next-generation therapeutics.
The lab focuses in particular on disease chemical biology, which explores disease mechanisms through chemistry, and on drug discovery using mid-sized molecules.
Key terms
- Chemical Biology
- A field that uses chemical methods to investigate and manipulate the mechanisms of life
- Mid-sized molecules
- Molecules intermediate in size between conventional drugs (small molecules) and large molecules such as antibodies. They include peptides and lipids
- Biomarker
- A substance in the body that indicates whether a disease is present and how far it has progressed
NewsLab news
Assistant Professor Hiroyuki Yatabe received the Young Researcher Excellence Award from the Society of Quantum Life Science
A student received the Student Excellent Presentation Award (Oral Presentation) at the Annual Meeting of the Pharmaceutical Society of Japan
Assistant Professor Yutaro Saito received the Young Scientists' Prize in the Commendation for Science and Technology by the Minister of Education, Culture, Sports, Science and Technology
A student received the Dean's Award of the School of Engineering, the University of Tokyo
Assistant Professor Yutaro Saito received the Progress Award of the Chemical Society of Japan
ResearchResearch themes
Built on large-scale molecule creation and high-throughput functional analysis, the lab systematically creates and evaluates structurally diverse biomolecules, aiming for a quantitative understanding of the relationship between molecular diversity and biological function. Its main application areas are "disease chemical biology" and "mid-sized molecule modality drug discovery."
*Illustrative imageSearching for Disease Markers
In the early diagnosis of diseases and the development of therapeutics, there is a serious shortage of disease-specific marker molecules. Through large-scale metabolic analysis using peptide libraries and other tools, the lab searches for biomarkers specific to each disease.
*Illustrative imageImaging Disease Metabolism
Based on biomarker information, the lab combines molecular design that makes full use of organic chemistry with the latest technologies to develop molecular probes that visualize disease metabolism.
*Illustrative imageMaking Drugs from Peptides
Through research on peptides and peptidomimetics using its original molecular design technologies, the lab aims to realize mid-sized molecule peptide drug discovery. It also uses data science to create functional peptides.
*Illustrative imageDesigning Lipids at Will
Lipids are biomolecules that are vital to life, but there is no technology to design and synthesize them freely, so much remains unexplored. By systematically designing lipids through solid-phase and automated synthesis, the lab tackles lipid-based drug discovery and the delivery of drugs into the body.
MembersFaculty
The Sando Lab consists of faculty members, postdoctoral researchers, visiting researchers, administrative and technical assistants, and graduate and undergraduate students.As of 2026
- ProfessorShinsuke SandoPublications ↗
- Associate ProfessorMorimoto JumpeiPublications ↗
- Assistant ProfessorHiroyuki YatabePublications ↗
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “Robot arm handles an assay plate” National Institute of Allergy and Infectious Diseases / Public domain (cropped)
- Searching for Disease Markers: “PDB 1su3 EBI” Jawahar Swaminathan and MSD staff at the European Bioinformatics Institute / Public domain (cropped)
- Imaging Disease Metabolism: “RenalCancer-250MBq-FDG-PET-CT Vergleich” Hg6996 / CC0 (cropped)
- Making Drugs from Peptides: “Ciclosporin-A-neutron-3D-sticks” Ben Mills / Public domain (cropped)
- Designing Lipids at Will: “The surface of highly curved lipid bilayer” Semen Yesylevskyy / CC BY 4.0 (cropped)
- Related lab (Okamoto Lab): “DNA methylation H o” Qubeat / CC BY-SA 4.0 (cropped)
- Related lab (Aida Lab): “Superabsorber Hydrogel KSG 2917 pK” Petra Klawikowski / CC BY-SA 3.0 (cropped)
- Related lab (Suzuki Lab): “3d tRNA” Vossman / CC BY-SA 3.0 (cropped)
- Related lab (Nozaki Lab): “Gas line IMG 20230205” Jonathansammy / CC BY-SA 4.0 (cropped)
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