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Laboratory Animal Science Lab
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The lab creates mouse models that replicate diseases in order to explore the mechanisms of inflammation.
AboutAbout the lab
Uncovering mechanisms with mice that replicate disease
The Laboratory Animal Science Lab uses genetic modification technology to create disease model mice that replicate diseases more faithfully, and uses them in its research.
Using these mice, the lab investigates how inflammatory diseases and infections arise, and also evaluates the effects of gut bacteria and of components derived from agricultural products.
Because animal experiments depend on the lives of animals, the lab also places importance on conducting appropriate animal experiments in line with the 3Rs principles.
In addition to the Department of Veterinary Medical Sciences, the lab accepts graduate students from the Department of Animal Resource Sciences, and welcomes those who graduated from faculties outside veterinary medicine.
Key terms
- Disease model mice
- Mice whose genes or other traits have been altered so that they show symptoms similar to those of human or animal diseases. They are used to study disease mechanisms and treatments.
- Cytokines
- Proteins that cells release to communicate with one another. They regulate inflammation and immune responses.
- 3Rs principles
- An ethical framework for animal experiments: replacing animals with non-animal methods, reducing the number of animals used, and refining procedures to reduce suffering.
NewsLab news
Published a paper on non-canonical translation initiation factors and heart function
Published a paper on a collaborative study of the gut colonization of recombinant E. coli
ResearchResearch themes
Using genetic modification technology, the lab creates disease model mice and mice for analysis, and studies how inflammatory diseases and infections arise. It also evaluates components derived from agricultural products using model animals, and develops techniques for creating genetically modified animals.
*Illustrative imageCreating new disease model mice
Using new technologies such as genome editing, the lab creates genetically modified mice that were previously difficult to produce. It is also developing mice for analysis, used in gut bacteria research, in collaboration with other research institutions.
*Illustrative imageThe role of inflammatory cytokines
The lab focuses on inflammatory cytokines such as IL-1 and IL-17, and on the molecules that regulate their production. It investigates the roles these play in inflammatory diseases such as cancer and dermatitis.
*Illustrative imageInvestigating the effects of components derived from agricultural products
Using disease model animals, the lab evaluates whether components derived from agricultural products are effective in preventing disease or reducing symptoms. In recent years, it has been studying the effects of Philippine propolis in collaboration with a university in the Philippines.
*Illustrative imageTechniques for creating genetically modified animals
The lab develops developmental engineering techniques for creating genetically modified animals. Using methods such as genome editing, this research forms the foundation for creating new kinds of genetically modified animals.
MembersFaculty
The members of the Laboratory Animal Science Lab consist of faculty, emeritus professors, doctoral, master's, and undergraduate students, academic specialist staff, and agricultural specific support staff.As of 2025
- Associate ProfessorShigeru KakutaPublications ↗
- Assistant ProfessorWataru FujiiPublications ↗
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “ChimericMouseWithPups” Staff at NIMH's Transgenic Core Facility / Public domain (cropped)
- Creating new disease model mice: “CRISPR-Cas9 Editing of the Genome ( )” National Human Genome Research Institute (NHGRI) / CC BY 2.0 (cropped)
- The role of inflammatory cytokines: “Interleukin-1-receptor+IL-1beta 1ITB” Ayacop / Public domain (cropped)
- Investigating the effects of components derived from agricultural products: “Propolis - 2017” Foto: Jonn Leffmann / CC BY 3.0 (cropped)
- Techniques for creating genetically modified animals: “Brinster Mouse Egg Microinjection” Credd7398 / CC BY-SA 4.0 (cropped)
- Related lab (Veterinary Pathology Lab): “Aβ deposits macaque neocortex” Tulemo / CC0 (cropped)
- Related lab (Veterinary Microbiology Lab): “Colorized transmission electron micrograph of Avian influenza A H5N1 viruses” CDC / Cynthia Goldsmith / Public domain (cropped)
- Related lab (Large Animal Clinical Medicine Lab): “Row of Holstein Friesian cows in Bronów” Mikinisk / CC BY-SA 4.0 (cropped)
- Related lab (Veterinary Hygiene Lab): “Laboratory rat” Anna Marchenkova / CC BY 4.0 (cropped)
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