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Molecular Biotechnology Lab
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The lab uses the cellular slime mold, an amoeba, to explore how cells divide, move, and eat.
AboutAbout the lab
Understanding how cells move, starting from amoeba cells.
The Molecular Biotechnology Lab uses cellular slime molds to study, at the molecular level, how cells move.
Cellular slime molds are single-celled amoebae that live in places such as forest undergrowth and multiply by eating bacteria.
Their shape and way of moving closely resemble those of animal white blood cells and cultured cells, which makes them a model organism for studying cell division, cell migration, and the uptake of food.
The lab studies cell division, migration, and phagocytosis, as well as the mechanisms of cell adhesion that support them.
Key terms
- Cellular slime mold
- A single-celled amoeba that lives in places such as forest undergrowth and multiplies by eating bacteria. It moves in ways similar to animal cells.
- Phagocytosis
- The process by which a cell engulfs large particles such as bacteria and takes them into the cell.
- Cytoskeleton
- A framework made of actin, microtubules, and other components that determines a cell's shape and generates its movement.
ResearchResearch themes
Using amoeba cells of the cellular slime mold, the lab analyzes at the molecular level cell motility in the broad sense, including cell division, migration, and the uptake of food, as well as the mechanisms of cell adhesion that support it. The goal is to clarify how cells change shape while controlling it with precision.
*Illustrative imageMechanisms of cytokinesis
Amoeba cells of the cellular slime mold divide in two in a way that closely resembles animal cultured cells. The lab searches for proteins involved in this division and investigates the functions of proteins such as those that bind to actin.
*Illustrative imageRoles of small G proteins
The lab investigates the functions of small G proteins (the Rho family) and the molecules that regulate them. These proteins control cell division, phagocytosis, and migration through the remodeling of the cytoskeleton.
*Illustrative imageHow cells attach to their substrate
The lab investigates how cells adhere to the substrate they move on, which is essential for cell migration, and how this adhesion relates to cell division and migration.
*Illustrative imageCell migration and phagocytosis
The lab investigates how cells move around and how phagocytosis, the uptake of food, works. It is also analyzing food preference in phagocytosis.
MembersFaculty
- Associate ProfessorHiroyuki AdachiPublications ↗
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “Dictyostelium discoideum 31” Usman Bashir / CC BY-SA 4.0 (cropped)
- Mechanisms of cytokinesis: “Human fibroblast undergoing cytokinesis” Reneferretti1 / CC BY 4.0 (cropped)
- Roles of small G proteins: “Fibroblastid (BPAE)” Heiti Paves / CC BY-SA 3.0 (cropped)
- How cells attach to their substrate: “Fibroblast (BPAE)” Heiti Paves / CC BY-SA 3.0 (cropped)
- Cell migration and phagocytosis: “Phagocytosis of a Dead Yeast Particle ( )” NIAID / CC BY 2.0 (cropped)
- Related lab (Molecular Breeding Lab): “20241028-R9HMNF-CB-001 Leafy ground” usfs_Eastern_Region / Public domain (cropped)
- Related lab (Food Biochemistry Lab): “Bodipy-wiki-Rkott-2023” Rkott / CC BY-SA 4.0 (cropped)
- Related lab (Fermentation Microbiology Lab): “Streptomyces griseus on chocolate agar (Espinoza 2022)” Carlos Espinoza, Pedro Morales, Brenda Perez, Alvaro Hu / CC BY 4.0 (cropped)
- Related lab (Microbial Ecotechnology Social Cooperation Lab): “Разнообразие почвенной микрофлоры в чашке Петри” Oksana Lastochkina / CC BY-SA 4.0 (cropped)
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