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Immune Regulation Lab
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A lab that aims to control immunity and allergy through food, starting from the mechanisms of intestinal immunity.
AboutAbout the lab
Unraveling the relationship between food and immunity
The Immune Regulation Lab studies the mechanisms of intestinal immunity and the regulation of immunity and allergy by food.
The intestine is in contact every day with the food that is eaten and with gut bacteria, making it one of the largest immune sites in the body.
The lab investigates how food allergy develops and how it is suppressed, as well as ways to modulate immune function with food components.
The lab is part of the Research Center for Food Safety in the Graduate School of Agricultural and Life Sciences.
Key terms
- Intestinal immune system
- The immune system of the intestine. While in contact with food and gut bacteria, it protects the body from pathogens.
- IgA antibody
- An antibody produced in large amounts in mucous membranes such as the intestine. It prevents pathogens from entering the body.
- Regulatory T cell
- An immune cell that suppresses immune responses so that they do not become too strong.
NewsLab news
Doctoral and master's students won poster awards at the Annual Meeting of the Japanese Society for Food Immunology
A doctoral student won a poster award at the Annual Meeting of the Japanese Society for Food Immunology
ResearchResearch themes
The lab aims to clarify how the intestinal immune system responds, and to control immunity through food by targeting these responses. In addition to suppressing food allergy, the lab studies the idea that reducing the risk of infection and lifestyle-related diseases through food also contributes to food safety in a broad sense.
*Illustrative imageFunctions of intestinal immune cells
The lab studies the functions of intestinal immune cells, such as how IgA antibodies are produced in the intestinal immune system and how regulatory T cells are generated through intestinal dendritic cells.
*Illustrative imageOnset and suppression of food allergy
The lab studies how food allergy develops and how it is suppressed. In collaboration with the Social Cooperation Program for Immune Biofunction Research, it also studies how allergy in the digestive tract reduces bone mass and how to suppress this.
*Illustrative imageImmune modulation by food components
The lab investigates whether food materials can increase IgA antibodies to enhance resistance to infection, and whether food materials can suppress the chronic inflammation associated with obesity and other conditions, thereby preventing lifestyle-related diseases and age-related diseases.
MembersFaculty
The members of the Immune Regulation Lab consist of faculty, project researchers, collaborative researchers, agricultural sciences specific support staff, academic specialist staff, and doctoral, master's, and undergraduate students.As of 2026
- ProfessorSatoshi HachimuraPublications ↗
- Project Associate ProfessorHaruyo Adachi (Nakajima)
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “Cross-section histology of small intestinal villi of the terminal ileum” Mikael Häggström, M.D. / CC0 (cropped)
- Functions of intestinal immune cells: “Dendritic cell revealed” National Institutes of Health (NIH) / Public domain (cropped)
- Onset and suppression of food allergy: “Roasted Peanuts with shell” Sanjay Acharya / CC BY-SA 4.0 (cropped)
- Immune modulation by food components: “DFC 2197 A colorful assortment of fresh fruits and vegetables - apples mango dragon fruit kiwis limes bananas and more - arranged on a wooden crate” PattayaPatrol / CC BY-SA 4.0 (cropped)
- Related lab (Plant Nutrition and Fertilizer Lab): “Roots of a hydroponically-grown plant” Banana patrol / CC BY-SA 3.0 (cropped)
- Related lab (Food Chemistry Lab (Arai Lab)): “Macrophage ( )” NIAID / CC BY 2.0 (cropped)
- Related lab (Food Biochemistry Lab): “Bodipy-wiki-Rkott-2023” Rkott / CC BY-SA 4.0 (cropped)
- Related lab (Nutrition and Life Sciences Lab): “Human iPS cells colonies” Christine Hale, Amy Yeung, David Goulding, Derek Pickard, Kaur Alasoo, Fiona Powrie, Gordon Dougan ほか
（PLOS ONE） / CC BY 4.0 (cropped)
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