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Kuroda Lab
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The lab seeks to understand cellular signaling and metabolism as a system.
AboutAbout the lab
Reading how cells work as a system
The Kuroda Lab studies the signaling and metabolic networks that regulate cellular functions.
Its goal is to describe these mechanisms quantitatively and understand them as a "system."
The lab analyzes them using both experimental methods and computer simulation.
Beyond cultured cells, it is also advancing organism-level analyses using disease model mice and human data.
Key terms
- Signal transduction
- The mechanism by which a cell receives a stimulus from outside and relays it inward through a chain of interacting molecules
- Trans-omics
- An approach that comprehensively measures multiple layers, such as metabolites, proteins, and mRNA, and analyzes them in an integrated way
- Simulation
- Running a model expressed in mathematical equations on a computer to reproduce or predict a phenomenon
NewsLab news
Paper published on the metabolic response of obese mice under fasting
Paper published on stratifying individuals using continuous glucose monitoring
Paper published on changes in gene and protein expression in obesity
Paper published on a method for early detection of declining blood glucose control capacity
Paper published on the robustness and fragility of metabolic networks during fasting
ResearchResearch themes
The lab aims to describe the mechanisms of signal transduction and metabolic regulation quantitatively, and to integrate them to understand them as a "system." Using both experimental methods and mathematical analysis and simulation, it approaches the functions of cells.
*Illustrative imageTrans-omics of insulin
Using metabolome and phosphoproteome data obtained through collaborations with other universities, the lab reconstructs the multilayered metabolic regulatory network controlled by insulin.
*Illustrative imageTemporal information coding
The lab proposed the idea that information is encoded in the temporal patterns of molecular activity. It shows how the waveform of insulin in the blood individually regulates downstream molecules.
*Illustrative imageInformation transmission in multicellular tissues
The lab separately measured variability between cells and variability within the same cell. It found that, at the tissue level, having variability allows finer discrimination between different stimuli.
*Illustrative imageHuman blood molecules after glucose intake
The lab characterizes the temporal concentration patterns of metabolites and hormones in human blood after oral glucose intake, comparing them across individuals and across molecules.
MembersFaculty
Members of the Kuroda Lab consist of faculty, doctoral, master's, and undergraduate students, academic specialists, and technical assistants.As of 2026
- ProfessorShinya KurodaPublications ↗
- Assistant ProfessorKeigo MoritaPublications ↗
- Project Assistant ProfessorMasaki ShiraiPublications ↗
- Project Assistant ProfessorEmiri WatanabePublications ↗
- Project Assistant ProfessorHideki MaeharaPublications ↗
VoicesStudent voices
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “Insulin Structure” Webridge / CC BY-SA 3.0 (cropped)
- Trans-omics of insulin: “Human-insulin-hexamer-3D-ribbons” Benjah-bmm27 / Public domain (cropped)
- Temporal information coding: “MA Amplitude modulation” Mister rf / CC BY-SA 4.0 (cropped)
- Information transmission in multicellular tissues: “Muscle fiber in bubble” Dedebio2015 / CC BY 4.0 (cropped)
- Human blood molecules after glucose intake: “Suckale08 fig3 glucose insulin day” Jakob Suckale, Michele Solimena / CC BY 3.0 (cropped)
- Related lab (Toyoshima Lab): “Adult Caenorhabditis elegans” Zeynep F. Altun, wormatlas.org / CC BY-SA 2.5 (cropped)
- Related lab (Katoh Lab): “Tree of life by Haeckel” Ernst Haeckel / Public domain (cropped)
- Related lab (Suzuki Lab): “Illumina HiSeq 2500” Konrad Förstner / CC0 (cropped)
- Related lab (Sugimura Lab): “Drosophila Melanogaster Wing” Kecko05 / CC0 (cropped)
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