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Sanada Lab
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A lab that uses mice to study how the brain is built and protected.
AboutAbout the lab
How the brain is built
The Sanada Lab studies how neurons in the brain are generated, migrate, mature, and are maintained.
The neocortex is found only in mammals and is thought to underlie higher-order functions such as perception, thought, and memory.
The lab mainly analyzes the mouse neocortex in vivo and in primary neuronal cultures.
The findings also contribute to understanding malformations of brain development and neurodegenerative diseases such as ALS and Alzheimer's disease.
Key terms
- Neocortex
- The part spreading over the surface of the cerebrum. Found only in mammals, it is responsible for perception, thought, memory, and more.
- Neural progenitor cell
- A cell at an intermediate stage of development that divides to give rise to neurons and glial cells.
- Neurodegenerative disease
- A disease in which neurons are gradually lost, such as ALS and Alzheimer's disease.
ResearchResearch themes
The lab investigates how the brain is built and maintained. Focusing mainly on the mouse neocortex, it studies the birth of neurons, their migration and maturation, neurogenesis in the adult brain, and the mechanisms that protect cells.
*Illustrative imageFate determination of neural progenitor cells
The lab investigates the mechanisms by which neural progenitor cells decide whether to self-renew or to become neurons or glial cells, focusing on signaling mediated by G protein-coupled receptors.
*Illustrative imageNeuronal migration and maturation
The lab identifies the molecules that act when newly born neurons migrate to their proper positions and mature by extending axons and dendrites, and analyzes how these molecules work.
*Illustrative imageAdult neurogenesis
Neurons continue to be generated in the adult brain, including in the hippocampus. The lab is pursuing its research based on the hypothesis that hippocampal neurogenesis is regulated by the circadian clock according to the time of day.
*Illustrative imageMechanisms that protect neurons
The lab analyzes the molecular mechanisms by which stressed neurons protect and maintain themselves. It has found multiple molecules that protect neurons.
MembersFaculty
The members of the Sanada Lab consist of faculty, doctoral and master's students, and secretarial staff.As of 2025
- Associate ProfessorKamon Sanada
- Assistant ProfessorYasuki NaitoPublications ↗
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “Synapsin and CamK2 positive neurons” ManuelSchottdorf / CC BY-SA 4.0 (cropped)
- Fate determination of neural progenitor cells: “Fluorescently labeled, DAPI-stained cell nuclei in a mouse coronal brain section” Syed07 / CC BY 4.0 (cropped)
- Neuronal migration and maturation: “Neuronal Dendrites Finding A Path” Dchordpdx / CC BY 4.0 (cropped)
- Adult neurogenesis: “Dentate gyrus II” National Institutes of Health (NIH) / Public domain (cropped)
- Mechanisms that protect neurons: “The Galaxy Within” Dchordpdx / CC BY 4.0 (cropped)
- Related lab (竹内研究室): “Mouse olfactory bulb @ 20x ( )” Jason Snyder from Washington, DC, United States / CC BY 2.0 (cropped)
- Related lab (國友研究室
（分子 行動遺伝学） ): “Varbuss” Heiti Paves / CC BY-SA 3.0 (cropped) - Related lab (塩見研究室): “Drosophila melanogaster - side (aka)” André Karwath aka Aka / CC BY-SA 2.5 (cropped)
- Related lab (上村研究室): “Nanopore Sequencing ( )” National Human Genome Research Institute (NHGRI) from Bethesda, MD, USA / CC BY 2.0 (cropped)
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