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Uemura Lab
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The lab observes the individuality of single molecules and single cells using its own original technologies.
AboutAbout the lab
Studying the individuality of molecules and cells
The Uemura Lab studies the "individuality" of single molecules and single cells.
Even among cells or molecules of the same type, each one behaves differently, but when they are measured together, the results are averaged and these differences become invisible.
Using original technologies that examine single molecules and single cells in detail, the lab aims to achieve personalized diagnosis of diseases, develop new drugs, and elucidate the mechanisms of molecules.
Key terms
- Nanopore
- A tiny pore about a nanometer in size. The structure of a molecule can be read one molecule at a time from the change in electric current as the molecule passes through.
- Single-molecule measurement
- A method that directly measures the movement or reaction of each individual molecule, rather than the average of many molecules.
- Nucleosome
- The basic unit of a chromosome, in which DNA is wound around proteins called histones.
NewsLab news
Research on identifying molecules using nanopores and machine learning published in Chemical Science
Master's student wins Student Presentation Award at the Annual Meeting of the Biophysical Society of Japan
Study on the process of nucleosomal DNA unwinding published in Communications Biology
Student who carried out undergraduate thesis research in the lab wins the Academic Encouragement Award from the Faculty of Science, the University of Tokyo
ResearchResearch themes
The lab aims to capture the differences between individual cells and molecules that disappear when they are averaged together. With single molecules and single cells as its keywords, it uses three original technologies to uncover new biological phenomena and aims to apply them to medicine.
*Illustrative imageDroplet-based technology for finding molecules
In a narrow microchannel, water is introduced into a flow of oil to rapidly produce uniform droplets of picoliter size. Using each droplet as an independent test tube, the lab develops methods for analyzing single molecules and single cells and for searching for molecules with useful functions.
*Illustrative imageSingle-molecule measurement with nanopores
The lab develops new nanopore technology that uses nanometer-sized pores to read the structure of molecules one at a time without labeling them. Its work has included measuring the process by which nucleosomal DNA unwraps from histones and developing a method that uses machine learning to identify proteins.
*Illustrative imageApproaching biological phenomena with new single-molecule measurements
ZMW (zero-mode waveguide) is a measurement method that can distinguish single molecules even amid strong fluorescence. The lab applies this method in its own way to newly advance single-molecule measurement of genome editing, RNA silencing, membrane proteins, and molecular motors.
MembersFaculty
The members of the Uemura Lab include faculty, project specialists, project researchers, and doctoral, master's, and undergraduate students.As of 2025
- ProfessorUemura SotaroPublications ↗
- Associate ProfessorItaru Yanagi
- Assistant ProfessorTomohiro ShimaPublications ↗
- Assistant ProfessorRyo IizukaPublications ↗
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “Nanopore Sequencing ( )” National Human Genome Research Institute (NHGRI) from Bethesda, MD, USA / CC BY 2.0 (cropped)
- Droplet-based technology for finding molecules: “T Junction Microfluidic Device” Wongbria / CC BY-SA 4.0 (cropped)
- Single-molecule measurement with nanopores: “Oxford Nanopore MinION side” Cirosantilli2 / CC BY-SA 4.0 (cropped)
- Approaching biological phenomena with new single-molecule measurements: “SequelSmrtCell” Owlmonkey / CC BY-SA 4.0 (cropped)
- Related lab (Nureki Lab): “Women operating Cryo EM” Tina Saey / CC BY 2.0 (cropped)
- Related lab (Siomi Lab): “Drosophila melanogaster - side (aka)” André Karwath aka Aka / CC BY-SA 2.5 (cropped)
- Related lab (Molecular Inflammation and Immunology Lab (Toyama-Sorimachi Lab)): “Macrophage ( )” NIAID / CC BY 2.0 (cropped)
- Related lab (Kunitomo Lab (Molecular Behavioral Genetics)): “Varbuss” Heiti Paves / CC BY-SA 3.0 (cropped)
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