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Ii Lab
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The lab uses numerical simulation to uncover how fluid flow and mechanics work inside the body.
AboutAbout the lab
Recreating biological phenomena with mechanics and computers.
The Ii Lab studies the mechanics behind biological phenomena, mainly those involving flow and transport, using numerical simulation.
The lab aims to establish a new research approach that integrates numerical analysis with real data obtained from experiments and clinical measurements.
Keywords are biomechanics, computational mechanics, cerebral circulation, multiscale phenomena (such as cell membranes and the cytoskeleton), data assimilation, and machine learning.
Assistant Professor Hiro Wakimura studies high-resolution numerical methods in computational fluid dynamics and compressible gas-liquid two-phase flow.
The lab was established in April 2024.
Key terms
- Data assimilation
- A mathematical-science method that incorporates measurable data, such as velocity and shape, into a physical model to reconstruct a state in a way that follows physical laws
- Microcirculation
- The circulation of blood through thin vessels with diameters of a few micrometers to several tens of micrometers
- PINN
- A neural network that incorporates physical laws (Physics-Informed Neural Network)
NewsLab news
Paper on an incompressible fluid solver using a meshless method with a staggered arrangement accepted by Computers & Fluids
Feature article on the dynamic behavior of bubbles under ultrasound published in the Japanese journal Multiphase Flow (Konsoryu)
Paper on red blood cell flow patterns in curved microvessels published in Physical Review Fluids
Paper on data-driven synthetic geometries for systematic CFD analysis of cerebral aneurysms accepted by Journal of Biomechanical Science and Engineering
Paper on estimating unsteady instantaneous flow fields with PINNs accepted by Journal of Biomechanical Science and Engineering
ResearchResearch themes
The lab reproduces biological phenomena involving flow and transport through numerical simulation and investigates their underlying mechanics. Its targets include blood flow in the brain, red blood cells flowing through microvessels, and the mechanics inside cells and vessel walls. The lab also works on methods that combine measurement data with numerical analysis, and on developing new computational methods.
*Illustrative imageCerebral Blood Vessels and Blood Flow in Cerebral Aneurysms
The lab studies a method for determining blood flow inside cerebral aneurysms through data assimilation, which incorporates measured blood velocity data into a mathematical model. It also works on systematic analysis of blood flow by generating diverse cerebral aneurysm shapes from data. The lab has also worked on research toward a digital twin of human cerebral circulation, realized on the supercomputer Fugaku.
*Illustrative imageRed Blood Cells and Oxygen in Microvessels
The lab investigates blood flow in the microcirculation using computational models that couple red blood cell deformation with blood flow. It analyzes how the flow behavior and effective viscosity of red blood cells change in curved capillaries, as well as oxygen transport and metabolism in the microcirculation.
*Illustrative imageMechanics Inside Cells and Vessel Walls
Using numerical models, the lab studies the clustering of integrins in the early stage of cell adhesion, and fluctuations in cell cortex tension driven by myosin. It also uses numerical analysis to address interstitial flow through the wall of the aorta (the tunica media) and the transport of substances within brain tissue.
*Illustrative imageComputational Methods for Solving Complex Biological Flows
The lab develops the mesh-constrained discrete point method and a least-squares-based meshless method as approaches to problems such as incompressible flows with moving boundaries. It also uses PINNs to reconstruct the instantaneous flow field of pulsatile blood flow downstream of a stenosis from time-varying velocity data. Assistant Professor Wakimura studies numerical methods that solve problems such as compressible gas-liquid two-phase flow at high resolution.
MembersFaculty
In addition to the faculty, the Ii Lab has 2 researchers, 2 doctoral students, 7 master's students, 2 fourth-year undergraduate students, and 1 non-degree graduate research student (according to the lab's website).
- ProfessorIi SatoshiPublications ↗
- Assistant ProfessorHiro WakimuraPublications ↗
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “Aneurysma A cerebri media” Hellerhoff / CC BY-SA 3.0 (cropped)
- Cerebral Blood Vessels and Blood Flow in Cerebral Aneurysms: “Aneurysem” Lucien Monfils / CC BY-SA 3.0 (cropped)
- Red Blood Cells and Oxygen in Microvessels: “A red blood cell in a capillary, pancreatic tissue - TEM” Louisa Howard / Public domain (cropped)
- Mechanics Inside Cells and Vessel Walls: “Elastic lamellae in aorta” Rustredrobot / CC BY-SA 4.0 (cropped)
- Computational Methods for Solving Complex Biological Flows: “Unfitted mesh-overlapping domains” Greegg0 / CC0 (cropped)
- Related lab (八木研究室): “Axons Al Dente” MikeRoscopy / CC BY 4.0 (cropped)
- Related lab (肖研究室): “Rayleigh-Taylor instability” Lawrence Livermore National Laboratory / Public domain (cropped)
- Related lab (西迫研究室): “T Junction Microfluidic Device” Wongbria / CC BY-SA 4.0 (cropped)
- Related lab (高山研究室): “Worm drive ( )” Bernard Spragg. NZ from Christchurch, New Zealand / CC0 (cropped)
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