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Molecular and Cellular Biology Lab
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The lab uses the peroxisome as a model to explore how organelles are formed.
AboutAbout the lab
Unraveling the mechanisms of life from a small organelle.
The Molecular and Cellular Biology Lab uses the peroxisome, one of the intracellular organelles, as a model to study at the molecular level how it is formed and regulated, and how its dysfunction leads to disease.
Peroxisomes carry out many important metabolic functions, and their dysfunction causes fatal genetic diseases.
The lab also aims to elucidate the issues grouped under the name "protein kinesis," including how proteins that carry out life processes are sorted and transported within cells, how organelles are formed, and how biological membranes are formed.
Professor Shigehiko Tamura's primary affiliation is the Faculty of Arts and Science, with a concurrent appointment in the Department of Systems Life Sciences, Graduate School of Systems Life Sciences.
Key terms
- Organelle
- A small structure inside a cell that has its own specific function. Also called an intracellular organelle
- Peroxisome
- One of the intracellular organelles. It carries out many important metabolic functions, and its dysfunction leads to genetic diseases
- Protein kinesis
- A name for a group of research issues, including the sorting and transport of proteins within cells and the formation of organelles and biological membranes
ResearchResearch themes
Using the peroxisome as a model organelle, the lab seeks to clarify at the molecular level how it is formed and regulated, and how its dysfunction causes disease. The research also extends to the transport of proteins within cells and the mechanisms that maintain protein homeostasis.
Peroxisome formation and disease
Using the peroxisome as a model organelle, the lab seeks to clarify at the molecular level the mechanisms of its formation and regulation and of how its dysfunction leads to disease, with the aim of understanding how proteins are sorted and transported and how biological membranes are formed (Professor Tamura).
Mechanisms that maintain protein homeostasis
The lab studies at the molecular level the mechanisms that maintain homeostasis of proteins and organelles within cells, and how diseases arise when these mechanisms break down. Work includes the formation of protein complexes and their quality control (Assistant Professor Yagita).
MembersFaculty
- ProfessorShigehiko Tamura
- Assistant ProfessorYuichi Yagita
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