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Suzuki Lab
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The lab explores how cells and parts of cells that are no longer needed are removed.
AboutAbout the lab
From understanding life phenomena to medicine.
The Suzuki Lab studies how cells and parts of cells that are no longer needed in the body are recognized and removed.
In the human body, many cells die every day and are eaten by phagocytes, while almost the same number of cells are produced at the same time, which keeps organs in good condition.
Because failure of this removal can lead to diseases such as autoimmune diseases and cancer, the lab focuses on the mechanisms of removal.
The lab is based at the Institute for Integrated Cell-Material Sciences (iCeMS) of the Institute for Advanced Study, and it participates as a cooperating division of the Graduate School of Biostudies. Students join the lab from graduate school.
Key terms
- Phagocyte
- A cell that takes in and breaks down dead cells and unneeded material. This engulfing action is called phagocytosis
- Organ renovation
- The lab's name for the process in which unneeded cells are removed and almost the same number of new cells are produced, so that an organ is maintained
- Lipid dynamics
- Changes in the arrangement and distribution of the lipids that make up membranes such as the plasma membrane. They can also serve as a marker of unneeded cells
- Screening
- A method of examining many genes or other candidates at once to sort out and find the factors involved in a given phenomenon
NewsLab news
Paper on using a synthetic ligand to have phagocytes remove target cells published in Nature Biomedical Engineering
Paper on an in vivo CRISPR screening method targeting mouse testicular cells published in STAR Protocols
ResearchResearch themes
The lab focuses on how unneeded substances, intracellular compartments, and cells arise, and how they are recognized and removed by the body's mechanisms. In particular, it studies lipid dynamics in the plasma membrane of unneeded cells and their removal by phagocytes.
Renovation at the organ level
In organs, unneeded cells undergo cell death and are eaten by phagocytes, while almost the same number of cells are produced, which maintains the condition of the organ. The lab calls this process "organ renovation." Because failure of removal can lead to autoimmune diseases and cancer, it investigates the mechanisms of removal.
Renovation of neurons in the brain
Neurons in the adult brain cannot proliferate and cannot easily die, so unneeded parts such as synapses and axons are eaten and removed by phagocytes. The lab calls this process "cell renovation," and it aims to elucidate the mechanisms with possible links to neurodegenerative and psychiatric disorders in mind.
Lipid dynamics and control of removal
The lab places particular emphasis on lipid dynamics in the plasma membrane of unneeded cells and on their removal by phagocytes. It is also attempting to control the removal of unneeded substances and cells that accumulate in the body with aging, using synthetic approaches.
Membrane lipid dynamics and technologies for finding regulatory factors
Lipid dynamics are also involved in sperm fertilization, stress responses, immunity, and lipid synthesis in organelles. The lab investigates how membrane proteins regulate lipid dynamics, and it is also developing screening technologies to identify the regulating factors.
MembersFaculty
The Suzuki Lab's members include faculty, researchers, PhD and master's students, laboratory assistants, and secretaries.As of 2026
- ProfessorJun Suzuki
- Assistant ProfessorSayuri Motani
- Program-Specific Assistant ProfessorKeiichiro Uchida
- Program-Specific Associate Professor (Research Base)Tomoko Inose
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